Immuno/GI Flashcards
1
Q
Cyclosporine
MOA:
A
Calcineurin inhibitor; binds cyclophilin. Blocks T-cell activation by preventing IL-2 transcription.
2
Q
Tacrolimus (FK506)
MOA:
A
Calcineurin inhibitor; binds FK506 binding protein (FKBP). Blocks T-cell activation by preventing IL-2 transcription.
3
Q
Sirolimus (rapamycin)
MOA:
A
mTOR inhibitor; binds FKBP. Blocks T-cell activation and B-cell differentiation by preventing response to IL-2.
4
Q
Daclizumab,
basiliximab
MOA:
A
Monoclonal antibodies;
block IL-2R. (CD25)
5
Q
Azathioprine MOA:
A
Antimetabolite precursors of 6-MP; inhibits lymphocyte proliferation by blocking nucleotide synthesis
6
Q
Nephrotoxicity
A
Cyclosporine and tacrolimus
7
Q
Similar to cyclosporine, risk of diabetes and neurotoxicity; no gingival hyperplasia or hirsutism.
A
tacrolimus
8
Q
Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells.
A
Mycophenolate mofetil
9
Q
inhibits production of guanine so it can’t have DNA replication
A
Mycophenolate mofetil
10
Q
What drug causes avascular necrosis of the femoral head?
A
Corticosteroids
11
Q
Inhibit NF-κB. Suppress both B- and T-cell function by transcription of many cytokines. Induce apoptosis of T lymphocytes.
A
Corticosteroids
12
Q
Decoy TNF-alpha receptor and is not a monoclonal antibody
A
etanercept
13
Q
CD20 Monocolonal Ab
A
Rituximab
14
Q
Platelet glycoproteins IIb/IIIa
A
Abciximab
15
Q
IgE
A
Omalizumab
