Immuno/GI

Question 1

Cyclosporine

MOA:

Answer 1

Calcineurin inhibitor;
binds cyclophilin.
Blocks T-cell
activation by
preventing IL-2
transcription.

Question 2

Tacrolimus (FK506)

MOA:

Answer 2

Calcineurin inhibitor; 
binds FK506 binding
protein (FKBP).
Blocks T-cell activation
by preventing IL-2
transcription.

Question 3

Sirolimus (rapamycin)

MOA:

Answer 3

mTOR inhibitor; binds
FKBP.
Blocks T-cell
activation and B-cell
differentiation by
preventing response
to IL-2.

Question 4

Daclizumab,
basiliximab
MOA:

Answer 4

Monoclonal antibodies;

block IL-2R. (CD25)

Question 5

Azathioprine MOA:

Answer 5

Antimetabolite precursors of 6-MP; inhibits lymphocyte proliferation by blocking nucleotide synthesis

Question 6

Nephrotoxicity

Answer 6

Cyclosporine and tacrolimus

Question 7

Similar to cyclosporine,
􀁱 risk of diabetes and
neurotoxicity; no
gingival hyperplasia
or hirsutism.

Answer 7

tacrolimus

Question 8

Reversibly inhibits
IMP dehydrogenase,
preventing purine
synthesis of B and T
cells.

Answer 8

Mycophenolate mofetil

Question 9

inhibits production of guanine so it can’t have DNA replication

Answer 9

Mycophenolate mofetil

Question 10

What drug causes avascular necrosis of the femoral head?

Answer 10

Corticosteroids

Question 11

Inhibit NF-κB.
Suppress both B- and
T-cell function by
􀁲 transcription of
many cytokines.
Induce apoptosis of T
lymphocytes.

Answer 11

Corticosteroids

Question 12

Decoy TNF-alpha receptor and is not a monoclonal antibody

Answer 12

etanercept

Question 13

CD20 Monocolonal Ab

Answer 13

Rituximab

Question 14

Platelet glycoproteins IIb/IIIa

Answer 14

Abciximab

Question 15

IgE

Answer 15

Omalizumab

Question 16

G-CSF recombinant cytokine

Answer 16

Filgrastim (use for bone marrow recovery)

Question 17

block the final common pathway of gastric acid secretion from parietal cells which is simulated by acetylcholine, histamine and gastrin.

Answer 17

proton pump inhibitors like lansoprazole