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Pulmonary > Random Pulmonary > Flashcards

Random Pulmonary Flashcards

1
Q

naloxone

A
  • given to treat morphine overdose
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2
Q

atelectasis

A
  • collapse of lung volume

- pulls lung and trachea towards it

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3
Q

pleural effusion

A
  • filling of pleural space with liquid

- pushes trachea in opposite direction

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4
Q

pleurodesis

A
  • a medical procedure in which the pleural space is artificially obliterated.[1] It involves the adhesion of the two pleurae.
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5
Q

thoracentesis

A
  • a procedure to remove fluid from the space between the lungs and the chest wall called the pleural space. It is done with a needle (and sometimes a plastic catheter) inserted through the chest wall.
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6
Q

OSA (obstructive sleep apnea)

A

x

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7
Q

OHS ( obesity hypoventilation syndrome)

A

x

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8
Q

cheyne stokes syndrome

A

x

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9
Q

MUDPILES (Anoin gap)

A 
Methanol
Uremia
DKA (and other ketoacids, namely EtOH and starvation)
Propylene Glycol
INH
Lactate
Ethylene Glycol
Salicylates
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10
Q

vocal cord layers

A
  • Epithelium
  • Superficial Lamina Propria
  • Intermediate Lamina Propria
  • Deep Lamina propria
  • Vocalis muscle (medial thyroarytenoid)
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11
Q

COPD

A

COPD is defined by fixed airflow limitation

FEV1/FVC

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12
Q

Blue Bloater

A

Hypoventilator
Hypoxic
Hypercapnic

Cor pulmonale

Historically
chronic bronchitis

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13
Q

Pink Puffer

A

Hyperventilator
Less hypoxia /
hypercapnia

Historically
emphysema

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14
Q

Rhonchi

A

are rattling, continuous and low-pitched breath sounds that are often hear to be like snoring. also called low-pitched wheezes. They are often caused by secretions in larger airways or obstructions.

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15
Q

Acute COPD Exasperation

A

Increased cough
Sputum volume and purulence
Increased wheezing

Worsening obstruction on PFTs
Unchanged CXR

Precipitated by infection, pollution, PE, unknown factors

Increased work of breathing due to hyperinflation, increased airway resistance
Treated with bronchodilators, steroids, antibiotics

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16
Q

Management of Bronchiectasis

A

Airway clearance – to promote clearance of secretions
Antibiotics – may be intermittent, chronic, or rotating courses.
Treat reactive airways disease
Bronchodilators, corticosteroids

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17
Q

Bronchiolitis

A

In kids
Related usually to infection (i.e. RSV)

In adults
Related to infection (esp. mycoplasma) 
less common than in kids
Non-infectious causes
Toxins, collagen vascular disease (e.g. RA), smoking
Lung transplant chronic rejection
Hypersensitivity pneumonitis
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18
Q

Cromolyn/nedocromil

A

• administered by the inhaled route
• • mechanism of action: inhibition of mast cell mediator release
• beneficial effect
preventative therapy for exercise-induced asthma can prevent allergen-induced pulmonary response

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19
Q

Theophylline

A

• administered by the oral or intravenous route
• mechanism of action: inhibition of phosphodiesterase
• beneficial effect: bronchodilator effect and some anti-inflammatory activity
• adverse effect:
caffeine-like effects such as irritability, gastrointestinal distress.
very narrow therapeutic range and requires blood level monitoring to individualize dose. Significant adverse effects can include seizures and irreversible neurologic damage

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20
Q

Systemic Circulation

A

High resistance
High Elastance/Low Compliance
High pressure
(CO=5L/min)

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21
Q

Pulmonary Circulation

A

Low resistance
Low Elastance/High Compliance
Low pressure (CO=5L/min)

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22
Q

Pulmonary edema types

A

Cardiogenic

  • Increased vascular hydrostatic pressure forces liquid out into lung tissue
  • Kerley B lines
  • use diuretics
  • Left PCWP pressure increased

non-cardiogenic

  • inflammation
  • leaky vascular walls
  • can be due to ARDS/pneumonia
  • diuretics don’t help
  • Left PCWP pressure increased not increased
  • Can be due to accident where legs are crushed and inflammation occurs at lung blood vessels and they become more permeable
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23
Q

Pulmonary hypertension

A
  • Mean pulmonary arterial pressure > 25 mmHG (normal is 15-18)

Pre-capillary

  • (Pulmonary Arterial Hypertension; PAH)
  • PCWP ≤ 15mmHg
  • acute PE
    • Pneumonia (hypoxic vasoconstriction)
    • hypoxia
    • thromboembolism

Post-capillary

  • (Pulmonary Venous Hypertension; PVH)
  • PCWP > 15mmHg
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24
Q

Increased PA Pressure Can be Due to:

A
  1. Increased pulmonary vascular resistance
  2. Increased left atrial pressure
  3. Increased cardiac output– rarely by itself
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25
Q

Pulmonary embolism

A

Results in RV strain (“submassive”) / failure (“massive”)

  • Increased myocardial O2 demand
  • Decreased myocardial O2 delivery
  • Cycle leading to death
  • can result from DVT also
Chest xray
- Hampton’s Hump
(Infarcted Lung)
- Westermark’s Sign
(Hypoperfusion)
  • elevated D-dimer
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26
Q

Pulmonary embolism treatment

A 
Stable (submassive)
Parenteral Anticoagulation
Heparin: Unfractionated or low molecular weight
Catheter directed thrombolysis (tPA)
Oral Anticoagulation - warfarin
Unstable (hypotensive, RV failure = massive)
Heparin
Consider thrombolysis (tPA)
Consider IVC Filter
Consider surgical thrombectomy
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27
Q

Clinical Classification of Pulmonary Hypertension: WHO Groups

A
  1. Pulmonary Arterial Hypertension
  2. PH Due to Left Heart Disease
  3. PH Due to Lung Diseases and/or Hypoxia
  4. Thromboembolic Pulmonary Hypertension
  5. PH With Unclear/Multifactorial Mechanisms
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28
Q

Pulmonary Arterial Hypertension (precapillary)

A

Mean PAP ≥25 mm Hg plusPCWP/LVEDP ≤15 mm Hg plusPVR > 3 Wood Units

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29
Q

PAH PHYSICAL EXAM

A

Neck veins: distended
Lung auscultation: normal (no rales)
Cardiac exam; loud P2, murmur of TR
Extremities: edema

30
Q

Treatment of PVH (pulmonary venous hypertension)

A

Decrease intravascular filling
Limit fluid intake
Limit sodium intake
Diuresis

Improve LV contractility
Decrease LV aferload (control systemic hypertension)

Correct causes of LV failure
Ischemia
Valvular disease

Do Not Use PAH specific therapy for PVH!!!!

31
Q

Factors that affect ventilation (VA)

A

Obstructive disease (e.g., COPD)
Compliance problems
Generally, total ventilation is affected only by severe disease conditions.
Exercise (ventilation can increase up to 10-fold)
Gravity (introduces regional variations in ventilation)
High altitude

32
Q

Bohr effect

A

CO2 binding reduces O2 affinity for Hb

33
Q

Haldane effect

A

O2 binding reduces CO2 affinity for Hb

34
Q

Hypoxia

A

Low O2 in tissue

due to low Q or low arterial o2 saturation with hypoxemia

35
Q

Hypoxemia

A

low arterial blood O2 saturation

36
Q

Intracellular buffer

A

Organic Phosphates
Proteins
Hemoglobin

37
Q

Extracellular buffers

A

Proteins
Albumin
Phosphate
Bicarbonate

38
Q

Normal pH

A

7.38-7.43 (bit higher in Denver)

39
Q

Normal venous pH

A

range 7.34-7.37

40
Q

Hemoglobin Buffering

A

Deoxyhemoglobin is such a good buffer that venous pH is only slightly lower and venous pCO2 is only slightly higher (~45 Torr) than arterial blood despite amount of CO2 being carried

41
Q

Two categories of metabolic acidosis:

A

Anion Gap

Non-Anion Gap

42
Q

Non-Anion gap is caused by loss of bicarbonate

A 
GI losses (severe gonnorhea)
Renal losses
43
Q

metabolic alkalosis causes

A

Vomiting or NG tube suction (loss of gastric acid)
Ingestion NaHCO3
Ingestion of other alkali (milk-alkali syndrome)
Hypovolemia, so-called contraction alkalosis
Diuretics

44
Q

Peripheral chemoreceptors

A

Located in carotid bodies
Mediate increases in ventilation in response to:
- Low arterial O2 (relatively insensitive until PaO2

45
Q

Properties of central chemoreceptors

A

Located on ventral surface of medulla (in the brain!)
Bind protons in CSF but sense arterial CO2
Response is slow (minutes)
Mediate 80% of ventilatory response to high PaCO2 under long-term conditions
Most important day-to-day regulator of ventilation

46
Q

Motor neurons that control respiratory muscles

A

 Tidal Volume

 Breathing Rate

47
Q

Crackles and rales

A

discontinuous and typically during inspiration; Specific cause is not clear; “Velcro sound” ;

Associated with:
Pulmonary edema
Pneumonia
Interstitial lung disease/fibrosis

48
Q

5 causes of hypoxemia

A

Normal A-a O2 gradient

Altitude
Hypoventilation
-OHV (obesity hypoventilation)
-central apnea aka Ondine’s curse
-neuromuscular dz (Lou Gerhigs, myasthenial gravis)
-Drugs (opiates, benzo)
49
Q

Low V/Q causes

A 
Hypoventilation
Asthma
Chronic Bronchitis
Emphysema (late)
ILD (interstitial – fibrosis)
50
Q

Shunt causes

A 
Pulmonary Edema
ARDS
Pneumonia
Intracardiac/Congenital Heart Dz
Pulmonary AVM
arteriolevenous malformation
Atelectasis
51
Q

sildenafil

A

treatment for PAH. vasodilator

52
Q

Acute restrictive diseases

A

Pulmonary edema
ARDS/DAD
Pneumonia
Pleural effusion

53
Q

Chronic restrictive diseases

A

ILD - interstitial lung diseases
Pleural fibrosis / plaques
Pleural effusion

54
Q

ALS is often called Lou Gehrig’s disease

A

A nervous system disease that weakens muscles and impacts physical function.

Difficulty walking, tripping or difficulty doing your normal daily activities
Weakness in your leg, feet or ankles
Hand weakness or clumsiness
Slurring of speech or trouble swallowing
Muscle cramps and twitching in your arms, shoulders and tongue
Difficulty holding your head up or keeping a good posture

Respiratory muscle weakness
Inadequate ventilation (CO2 rises)
Nocturnal hypoventilation (worse than normal people where brain is asleep and breathing decreases a bit at night)
Weak cough

Major: Dysphagia –> lots of recurring pneumonia from aspiration

TREATMENT
Noninvasive positive pressure ventilation to help breathe)
Aspiration precautions
Cough assistance

55
Q

guillain-barré syndrome

A

A condition in which the immune system attacks the nerves.

Prickling, “pins and needles” sensations in your fingers, toes, ankles or wrists
Weakness in your legs that spreads to your upper body
Unsteady walking or inability to walk or climb stairs
Difficulty with eye or facial movements, including speaking, chewing or swallowing
Severe pain that may feel achy or cramp-like and may be worse at night
Difficulty with bladder control or bowel function
Rapid heart rate
Low or high blood pressure
Difficulty breathing

56
Q

Rheumatoid arthritis

A

Pleuritis
Pleural Effusion
Pleural Thickening
Pneumothorax
Upper airway obstruction (cricoarytenoid arthritis)
Small airway obstruction (bronchiolitis,bronchiectasis)
Interstitial Lung Disease (UIP > NSIP)
Organizing pneumonia
Nodules
Pulmonary Hypertension
Vasculitis
Drug reactions (esp methotrexate, sulfasalazine)
Pulmonary infections due to immunosuppression

57
Q

IPF meds

A
  • nintedanib, pirfenidone

- Does not respond to anti-inflammatory meds

58
Q

Idiopathic Pulmonary Fibrosis

A

IPF is a scarring lung disease with a pattern of injury of
usual interstitial pneumonia (UIP).
Etiology is idiopathic.
(There are known causes for the same UIP pattern of injury).
Disease of older patients ( > 6th decade)
Associated with tobacco use
Cough, DOE, fatigue
Physical exam: Basilar predominant “velcro-crackles.” Digital clubbing in advanced cases.
Median survival from diagnosis is 2-3 years.

59
Q

Smoking

A
  • Chronic bronchitis
  • pneumonia
  • IPF
  • COPD
  • Emphysema
  • respiratory bronchiolitis
  • desquamative interstitial pneumonia
  • Pulmonary Langerhans Cell Histiocytosis
60
Q

Pulmonary Langerhans Cell Histiocytosis

A 
Young smokers
Imaging: cysts and nodules
Upper lobe predominant
Mixed PFTs
PTX common
15% extrapulm dz—including  bone lesions, pituitary  involvement
Treatment is smoking cessation
61
Q

Systemic diseases associated with diffuse alveolar hemorrhage and renal disease

A 
Granulomatosis with polyangiitis (formerly  Wegener’s)
Microscopic polyangiitis
Churg-Strauss Syndrome
Goodpasture’s Syndrome (Anti-GBM disease)
Systemic Lupus Erythematosus
Systemic Sclerosis (Scleroderma)
Henoch-Schonlein Purpura
Cryoglobulinemia
62
Q

Goodpasture’s Syndrome (Anti-GBM disease)

A

Goodpasture’s syndrome is an idiopathic disease that manifests as diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis.
Mediated by antibodies directed against glomerular basement membrane
Occurs almost exclusively in smokers

63
Q

Pulmonary Manifestations of Sickle Cell Disease

A

Infection
Embolic phenomena due to bone marrow infarction and fat emboli
Infarction caused by in-situ thrombosis
Hypoventilation due to rib and sternal infarctions
Pulmonary Edema due to excessive hydration
Pulmonary hypertension
Chronic lung disease

64
Q

Histiocytes and macrophages

A

As nouns the difference between macrophage and histiocyte is that macrophage is (immunology|cytology) a white blood cell that phagocytizes necrotic cell debris and foreign material, including viruses, bacteria, and tattoo ink it presents foreign antigens on mhc ii to lymphocytes part of the innate immune system while histiocyte is a macrophage, derived from bone marrow, found in connective tissue

65
Q

TGV (Thoracic Gas Volume)

A

represents the point when the inward recoil of the lung is exactly balanced by the outward recoil of the chest wall. This is measured at the end of a normal tidal volume. Anything that makes the lung stiffer (such as interstitial lung disease or loss of surfactant) without changing the chest wall compliance will decrease the TGV. Conversely anything that increases lung compliance (such as emphysema) will increase the TGV. Note that TGV and FRC both indicate the same thing but are measured differently. They should be the same in normal people, but can vary in disease.

66
Q

diet pills

A

pulmonary hypertension

67
Q

scleroderma

A

Chronic hardening and tightening of the skin and connective tissues. related to joint pain

68
Q

smoking and birth control pills

A

chronic thromboembolic disease

69
Q

cor pulmonale

A

(right heart failure due to

pulmonary hypertension).

70
Q

Pulmonary Hypertension facts

A

WHO Group 1 and WHO Group 4 disease will have
normal lung volumes and spirometry, and a decreased DLCO due to a decrease in
the vascular surface area.

71
Q

Loud P2

A

Pulmonary Hypertension

Pulmonary (10 decks)

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