Airway Diseases (Bronchioles)

Question 1

Chronic bronchiolitis

Answer 1

• chronic inflammation of bronchiole wall (mostly lymphocytes)
• from infection or autoimmune disease
• reversible if irritant removed
• RA is a strong connection

Question 2

Follicular Bronchiolitis

Answer 2

• germinal centers in lymphoid aggregates (b-cells in middle and t-cells outside)

Question 3

Constrictive bronchiolitis

Answer 3

• inflammation and fibrosis
• scarring bronchioles closed
• inflammation between mucosa and smooth muscle squeezing lumen close

Question 4

Obliterative bronchiolitis

Answer 4

• airway lumen obliterated by fibrosis

Question 5

Granulomatous bronchiolitis

Answer 5

• histiocytes and multinucleated giant cells (macrophages)
• may be necrotizing or nonnecrotizing
• necrotic due to infection of mycobacteria and fungus. dead pus with neutrophils
• nonnecrotic due to infection, sarcoid, beryllium