Random Oncology questions

Question 1

Which anti-neoplastic agents are available orally? (4)

Answer 1

capcitabine, temozolomide, procarbazine, hydroxyurea

Question 2

Which targeted therapies are available orally? (10)

Answer 2

Erlotinib, Lapatinib, Imatinib, Ponatinib, Sumitinib, Soratenib, Axitinib, Cicotinib, Ceritinib, Ruxolitinib

Question 3

Which chemo agents have a rash that correlates with efficacy?

Answer 3

the EGFR inhibitors (cetuximab and erlotinib)

Question 4

Which chemo drugs cause ocular toxicity?

Answer 4

cytarabine, carmustine, cicotinib and ceritinib

Question 5

Which chemo drugs cause hand-foot syndrome?

Answer 5

Anthracyclines (doxirubucin etc), Bleomycin (sausage digits!) and capecitibine.

Question 6

Which chemo drugs cause cardiotoxicity?

Answer 6

Traztuzumab, pertuzumab (HER 2), Anthracyclines (doxorubucin)

Question 7

Which chemo drugs are vesicants?

Answer 7

Anthracyclines (doxirubucin), Vinka alkaloids (vincristine), Nitrogen mustards (cyclophosphamide), and Mitomycin-C .

Question 8

which chemo drugs cause CIPN? (Chemotherapy induced peripheral neurophathy)

Answer 8

Vinca alkaloids (vincristine) (use warm compress), Anthracyclines (doxirubicin) (use cold compress), bortezomib.

Question 9

Which chemo drug can cause autonomic neuropathy? (and what does this manifest as?)

Answer 9

vinca alkaloids (severe constipation)

Question 10

Which chemo drugs cause myalgias?

Answer 10

taxanes (paclitaxel)

Question 11

Which chemo drugs cause hypersensitivity reactions?

Answer 11

Taxanes (paclitaxel), Rituxan, cetuximab, HER2 (traztuzumab etc)

Question 12

Which chemo drugs cause folic acid deficiencies?

Answer 12

Folate antimetabolites (methotrexate, pemetrexed etc)

Question 13

Which folate antimetabolite causes more nausea?

Answer 13

Pemetrexed

Question 14

Which folate antimetabolite causes more mouth sores?

Answer 14

Methotrexate

Question 15

Which chemo drugs cause edema?

Answer 15

Taxanes and interferons (IL-2), imatinib,

Question 16

Which taxane causes the most hypersensitivity rxns?

Answer 16

Paclitaxel (as apposed to dosetaxel)

Question 17

Which drug causes hypotension during infusion?

Answer 17

Etoposide (also aldesleukin (IL-2))

Question 18

which chemo drug causes hemorrhagic cystitis?

Answer 18

Cyclophosphamide

Question 19

Which chemo drugs cause pulmonary toxicity?

Answer 19

Bleomycin, cicotinib and ceritinib

Question 20

Which chemo drug causes CNS toxicity?

Answer 20

Procarbazine

Question 21

Which chemo drugs have a disulfaram like reaction?

Answer 21

Procarbazine

Question 22

Which chemo drugs can cause hepatotoxicity?

Answer 22

Kinase inhibitors (sunitinib), cicotinib, ceritinib, ipilimumab,

Question 23

Which chemo drugs can cause QTc prolongation?

Answer 23

Kinase inhibitors (sunitinib), cicotinib, ceritinib, lapatinib.

Question 24

Which chemo drug causes thrombocytopenia and anemia?

Answer 24

Jakafi (ruxolitinib)

Question 25

Which chemo drug can reactivate hepatitis C?

Answer 25

Rituximab and ofatimumab (anti CD 20)

Question 26

Which drug has a side effect of infections and can be prophylaxed with bactrim? (bonus: what is the main infections you see?)

Answer 26

Campath (alemtuxumab) (bonus: PCP)

Question 27

Which chemo drug can cause hypertension?

Answer 27

Bevacizumab

Question 28

Which chemo drug can cause a fistula?

Answer 28

Bevacizumab

Question 29

Which chemo drug is associated with derm toxicity?

Answer 29

Ipilimumab

Question 30

Which chemo drug is associated with Gullain-Barre?

Answer 30

Ipilimumab