Diabetes dosing

Question 1

Chlorpropamide

Answer 1

250mg PO QD, may increase by 50-125 mg at 3-5 day intervals.

Question 2

Glipizide

Answer 2

5mg PO QD initially. Titrate in 2.5-5 mg increments every few days. Max dose: 40 mg/day

Question 3

Glyburide

Answer 3

2.5-5mg PO QD. increase up to 2.5mg/day at weeky intervals. Max dose: 20mg/day

Question 4

Glimeperide

Answer 4

1-2 mg PO QD, may increase 1-2 mg q 1-2 weeks. Max: 8mg/day

Question 5

Metformin

Answer 5

500 mg BID, increased by 500 mg weekly until glycemic goals OR 2,000 mg/day

Question 6

Pioglitazone

Answer 6

15-30 mg QD

Question 7

Rosiglitazone

Answer 7

2-4 mg QD

Question 8

Acarbose and Miglitol (dosing is the same)

Answer 8

25 mg with one meal a day, increase gradually over several months to a max of 50mg TID if < 60 kg, or 100mg TID if >60 kg.

Question 9

Lantus and Levemir

Answer 9

Starting doses:
Type 1: .2-.4 U/kg
Type 2: 1 U per 20mg/dl above 100 fasting, 2 U per 20 mg/dl above 140 fasting

Question 10

Humalog, Novolog, Apidra

Answer 10

1 U per 12-15 grams of carbs

Question 11

Pramlintide

Answer 11

Type 1: 15 mcg prior to meals, can be titrated up in 15 mcg increments to a max of 60 mcg
Type 2: 60 mcg prior to meals, may be titrated to a max of 120 mcg.

Question 12

Exenatide

Answer 12

5 mcg BID, titrated to 10 mcg BID in 1 month, or as tolerability allows.

Question 13

Liraglutide

Answer 13

.6mg daily for >1 week, then 1.2 mg daily for > 1 week. pts may be maintained on the 1.2 mg dose or increased to the max 1.8 mg daily dose after > 1 week.

Question 14

Sitagliptin (Januvia)

Answer 14

100 mg PO QD

Question 15

Saxagliptin (Onglyza)

Answer 15

2.5-5 mg QD

Question 16

Alogliptin (Nesina)

Answer 16

25 mg PO QD

Question 17

Linagliptin (Tradjenta)

Answer 17

5 mg PO QD

Question 18

Canagliflozin (Invokana)

Answer 18

100 mg PO QD, may increase to 300 mg PO QD

Question 19

Colesevelam (Whelcol)

Answer 19

six 625 mg tablets daily. can be split into 3 tablets BID. Oral suspension packet also available.

Question 20

Dulaglutide (Trulicity)

Answer 20

.75 mg SC once weekly

Max of 1.5 mg once weekly.

Question 21

Albiglutide (Tanzuem)

Answer 21

30 mg SC once weekly, max 50 mg once weekly.

Question 22

Dapaliflozin (Farxiga)

Answer 22

5 mg PO QAM w or w/o food, may increase to 10 mg PO QAM.

Question 23

Bromocriptine mesylate

Answer 23

.8mg PO QD, may increase at weekly intervals in .8 mg incraments as tolerated. Usual dose: 1.6-4.8 mg/day.