Diabetes ADRs

Question 1

Sulfonylureas

Answer 1

Hypoglycemia, wt gain

Question 2

Metformin

Answer 2

Common:GI (anorexia, diarrhea, stomach fullness) Uncommon: metallic taste, interference with B12 absorption, hypoglycemia. Rare: Lactic acidosis

Question 3

TZDs

Answer 3

edema, wt gain, anemia, and elevated liver enzymes

Question 4

Miglitinides

Answer 4

hypoglycemia, wt gain

Question 5

Alpha-glucosidase inhibitors

Answer 5

GI, flatulence, bloating, abdominal discomfort, diarrhea. Hypoglyceia (not as monotherapy), elevated serum aminotransferase levels.

Question 6

Amylinomimetics

Answer 6

N/V anorexia

Question 7

GLP agonists

Answer 7

GI, hypoglycemia, acute pancreatitis. (Liraglutide: possibilbity of thyriod C-Cell tumors)

Question 8

DPP IV

Answer 8

Hypoglycemia in combo, headaches, nasopharngitis, edema, hypertension, cardiac outcomes

Question 9

Sodium glucose transporters

Answer 9

Increased K conc, renal insufficiency, hypovolemia, UTI

Question 10

Bile Acid sequestrants

Answer 10

GI- constipation dyspepsia, pyrosis (heartburn)

Question 11

Which drugs can cause Hypoglycemia as monotherapy?

Answer 11

Sulfonylureas, meglitinides, Insulin, GLP agonists,

Question 12

Which drugs can cause edema?

Answer 12

DPPIV and TZDs

Question 13

Dopamine agonists

Answer 13

Nausea, rhinitis, headache, asthenia (weakness), dizziness, constipation, and sinusitis

Question 14

Which drugs cause GI upset?

Answer 14

Metformin, Alpha-glucosidase inhibitors, Amylinomimetics, GLP agonists, Bile Acids sequestrants, Dopamine agonists

Question 15

Which drugs cause wt gain?

Answer 15

Sulfonylureas, TZDs, Meglitinides

Question 16

Which drugs may cause weight loss?

Answer 16

Metformin (mostly weight neutral), Sodium glucose transporters and pramlintide.

Question 17

Pramlintide BBW

Answer 17

hypoglycemia when used with insulin

Question 18

Liraglutide BBW

Answer 18

C-cell carcinoma in rats

Question 19

Which drugs primarily target Fasting Glucose

Answer 19

Metformin, TZDs,

Question 20

Which drugs primarily target post prandial glucose

Answer 20

Alpha-glucosidase inhibitors, DPPIV, Meglinitides, amylinomimetics, Sodium glucose transporters, Bile acid sequestrants, exenatide

Question 21

Which drugs target both post prandial and fasting glucose?

Answer 21

Liraglutide, SFU, dopamine agonist