Diabetes ADRs Flashcards
Sulfonylureas
Hypoglycemia, wt gain
Metformin
Common:GI (anorexia, diarrhea, stomach fullness) Uncommon: metallic taste, interference with B12 absorption, hypoglycemia. Rare: Lactic acidosis
TZDs
edema, wt gain, anemia, and elevated liver enzymes
Miglitinides
hypoglycemia, wt gain
Alpha-glucosidase inhibitors
GI, flatulence, bloating, abdominal discomfort, diarrhea. Hypoglyceia (not as monotherapy), elevated serum aminotransferase levels.
Amylinomimetics
N/V anorexia
GLP agonists
GI, hypoglycemia, acute pancreatitis. (Liraglutide: possibilbity of thyriod C-Cell tumors)
DPP IV
Hypoglycemia in combo, headaches, nasopharngitis, edema, hypertension, cardiac outcomes
Sodium glucose transporters
Increased K conc, renal insufficiency, hypovolemia, UTI
Bile Acid sequestrants
GI- constipation dyspepsia, pyrosis (heartburn)
Which drugs can cause Hypoglycemia as monotherapy?
Sulfonylureas, meglitinides, Insulin, GLP agonists,
Which drugs can cause edema?
DPPIV and TZDs
Dopamine agonists
Nausea, rhinitis, headache, asthenia (weakness), dizziness, constipation, and sinusitis
Which drugs cause GI upset?
Metformin, Alpha-glucosidase inhibitors, Amylinomimetics, GLP agonists, Bile Acids sequestrants, Dopamine agonists
Which drugs cause wt gain?
Sulfonylureas, TZDs, Meglitinides
Which drugs may cause weight loss?
Metformin (mostly weight neutral), Sodium glucose transporters and pramlintide.
Pramlintide BBW
hypoglycemia when used with insulin
Liraglutide BBW
C-cell carcinoma in rats
Which drugs primarily target Fasting Glucose
Metformin, TZDs,
Which drugs primarily target post prandial glucose
Alpha-glucosidase inhibitors, DPPIV, Meglinitides, amylinomimetics, Sodium glucose transporters, Bile acid sequestrants, exenatide
Which drugs target both post prandial and fasting glucose?
Liraglutide, SFU, dopamine agonist
