Diabetes drug contraindications

Question 1

sulfonylureas

Answer 1

elderly, decreased renal fx for those with active metabolites

Question 2

Metformin

Answer 2

Renal insufficiency, (GFR 1.4 for women or 1.5 for men), Age > 80, CHF, COPD, w/i 48 hours of radiocontrast die

Question 3

TZDs

Answer 3

liver disease or ALT > 2.5 ULN, NYHA class 3 or 4.

Question 4

Meglitinides

Answer 4

caution in renal and hepatic impairment

Question 5

Alpha-glucosidase inhibitors

Answer 5

patients with short-bowel syndrome or inflammatory bowel disease, patients with Scr >2

Question 6

DPP IV

Answer 6

Pancreatitis, DKA, HF, hepatic/ renal impairment. use w/ insulin may increase hypoglycemia

Question 7

SGTs

Answer 7

GFR <30, ESRD, dialysis, DKA

Question 8

Bile Acide Sequestrants

Answer 8

PMH of bowel obstruction or hypertriglyceridemia induced pancreatitis, TG> 500 mg/dl

Question 9

Dopamine Agonists

Answer 9

Pediatrics, pregnancy, combo with other hypoglycemic agents may increase risk of hypoglycemia