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Capstone Exam 2 > Oncology Brand/Generic/Class/MOA > Flashcards

Oncology Brand/Generic/Class/MOA Flashcards

1
Q

Claribine (gen)

A

Anti-metabolite (purine), Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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2
Q

Fludarabine (gen)

A

Anti-metabolite (purine), Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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3
Q

Xeloda

A

Capcitabine (oral), Anti-metabolite (Pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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4
Q

ARA-C

A

Citarabine (liposomal), Anti-metabolite (Pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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5
Q

5-FU

A

Florouricil, Anti-metabolite (Pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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6
Q

Gemzar

A

Gemcitabine, Anti-metabolite (Pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

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7
Q

Methotrexate (gen)

A

Anti-metabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

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8
Q

Alimta

A

Pemetrexid, Anti-metabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

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9
Q

Pralatrexate (gen)

A

Anti-metabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

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10
Q

Vidaza

A

Azacitidine, Antimetaboite (other), DNA methylation inhibitor
Direct cellular toxicity at abnormal bone marrow cells

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11
Q

Decogen

A

Decitabine, Antimetaboite (other), DNA methylation inhibitor
Direct cellular toxicity at abnormal bone marrow cells

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12
Q

Adriamycin

A

Doxorubucin, Anthracycline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
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13
Q

Doxil

A

Liposomal doxorubucin, Anthracycline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
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14
Q

Danorubucin (gen)

A

Anthracycline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
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15
Q

Epirubucin (gen)

A

Anthracycline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
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16
Q

Vincristine (gen)

A

(Liposomal) Microtubule (vinca alkaloids), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

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17
Q

Vinblastine (gen)

A

Microtubule (vinca alkaloids), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

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18
Q

Vinorelbine (gen)

A

Microtubule (vinca alkaloids), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

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19
Q

Taxol

A

Paclitaxel, Microtubule (Taxanes), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation

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20
Q

Taxotere

A

Docetaxel, Microtubule (Taxanes), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation

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21
Q

Abraxane

A

Paclitaxel- protein bound, Microtubule (Taxanes), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation

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22
Q

Ado-trastuzumab (gen)

A

Microtubule (other)Her-2 antibody conjugate with antimicrotubule inhibitor

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23
Q

Emtansine (gen)

A

Microtubule (other), Her-2 antibody conjugate with antimicrotubule inhibitor

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24
Q

Camptosar

A

Irinotecan, TOPO I inhibitor, Inhibits topo I (stabilizing the cleaved DNA strand, preventing re-ligation)

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25
Q

Hycamtin

A

Topotecan, TOPO I inhibitor, Inhibits topo I (stabilizing the cleaved DNA strand, preventing re-ligation)

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26
Q

Anthracycline (gen)

A

TOPO II, Inhibits topo II (re-ligation)

Other MOAs too

27
Q

Toposar

A

Etoposide, TOPO II, Inhibits topo II (re-ligation)

Other MOAs too

28
Q

Cytoxan

A

Cyclophosphamide, Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

29
Q

Iposphamide (gen)

A

Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

30
Q

Bendamustine (gen)

A

Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

31
Q

Carmustine (BCNU) (gen)

A

Alkylating agents (nitrosoureas), Alkylate DNA, causing cross-linking, inducing strand breakage

32
Q

Lomustine (gen)

A

Alkylating agents (nitrosoureas), Alkylate DNA, causing cross-linking, inducing strand breakage

33
Q

Streptozocin (gen)

A

Alkylating agents (nitrosoureas), Alkylate DNA, causing cross-linking, inducing strand breakage

34
Q

Temodar

A

Dacarbazine, Alkylating agent (triazense), Alkylate DNA at the O6, N7 position of guanine, causing cross-linking, inducing strand breakage.

35
Q

Temozolomide (gen)

A

ORAL, Alkylating agent (triazense), Alkylate DNA at the O6, N7 position of guanine, causing cross-linking, inducing strand breakage.

36
Q

Matulane

A

Procarbazine (oral), Alkylating agent (other), Inhibits transmethylation of methionine into tRNA; insight strand breakage

37
Q

Carboplatin (gen)

A 
Alkylating agent (platinum), Insights cross-linking
Violates the double-helix structure
Strand breakage
38
Q

Cisplatin (gen)

A 
Alkylating agent (platinum), Insights cross-linking
Violates the double-helix structure
Strand breakage
39
Q

Eloxitan

A

Oxaloplatin, Alkylating agent (platinum), Insights cross-linking
Violates the double-helix structure
Strand breakage

40
Q

Bleomycin (gen)

A

Antibiotic, Inhibits synthesis of DNA

And causes ROS

41
Q

Hydrea

A

Hydroxyurea (oral), Misc,Antimetabolite inhibiting ribonucleoside diphosphate reductase, preventing conversion of ribonucleotides to deoxyribonucleotides  halting cell cycle
Increases Hgb F levels

42
Q

Mitomycin-C (gen)

A

Misc, Alkylating agent, creates cross-linking with guanine and cytosine pairs.

43
Q

Tarceda

A

Erlotinib (oral), Anti-EGFR ORAL, EGFR selective TKI.

44
Q

Tykerb

A

Lapatinib (oral), EGFR and HER2 TKI.

45
Q

Gleevac

A

Imatinib (oral), BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML

*T351I mutation

46
Q

Dasatinib (gen)

A

BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML

*T351I mutation

47
Q

Iclusig

A

Ponatinib (oral), BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML

*T351I mutation

48
Q

Sutent

A

Sunitinib (oral), Kinase inhibitor, inhibit multiple receptor TKs.

49
Q

Nexavar

A

Soratenib (oral), Kinase inhibitor, inhibit multiple receptor TKs.

50
Q

Axitinib (oral)

A

Kinase inhibitor, inhibit multiple receptor TKs.

51
Q

Valcade

A

Bortezomib, proteosome inhibitor, Inhibits proteasomes, critical for protein homeostasis, inducing apoptosis

52
Q

Xalkori

A

Citotinib (oral), misc, ALK inhibition, ALK is a down-stream mutation causing constant “on” of proliferation; used in NSCLC

53
Q

Zykadia

A

Ceritinib (oral), misc, ALK inhibition, ALK is a down-stream mutation causing constant “on” of proliferation; used in NSCLC

54
Q

Jakafi

A

Ruxolitinib, misc, JAK1, JAK2 inhibition of the JAK-STAT signaling pathway. Used in myeloproliferative disorders with JAK2 mutations

55
Q

Rituxan

A

Rituximab, Anti-CD 20, Binds to CD20 on B cells, induces ADCC

56
Q

Azerra

A

Ofatumumab, Anti-CD 20, Binds to CD20 on B cells, induces ADCC

57
Q

Campath

A

Alemtuxumab, Anti-CD 52, Binds to CD 52 on B and T cells, inhibits interaction with other immune system functions, induces ADCC

58
Q

Erbitux

A

Certuximab, EGFR, Bind to and inhibit extracellular EGFR, induces apoptosis

59
Q

Herceptin

A

Trastuzumab, Her 2, Binds to HER2 at different points on the receptor, induces ADCC

60
Q

Perjeta

A

Pertuzumab, Her 2, Binds to HER2 at different points on the receptor, induces ADCC

61
Q

Ado-trastuzumab (gen)

A

Her 2, Binds to HER2 at different points on the receptor, induces ADCC

62
Q

Avastin

A

Bevacizumab, VEGF, Binds to circulating VEGF, inhibits the formation for vasculature, required for tumor growth

63
Q

Yervoy

A

Ipilimumab, CTLA-4, Binds to cytotoxic T-lymphocyte associated antigen 4 (CTLA-4), enhancing T-cell activation

64
Q

Aldesleukin

A

IL-2, Interferon, Cytokine, promoting B and T cell proliferation, anti-cancer therapy based on tumor susceptibility to lymphokine-activated killer cells and tumor-infiltrating lymphocytes

Capstone Exam 2 (8 decks)

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