RANDOM DERMPATH KODACHROMES

Question 1

Answer 1

Flame figure in wells syndrome

characteristic for, but not diagnostic of, Wells syndrome

foci of amorphous and/or granular material associated with connective tissue fibers

Question 2

Answer 2

Granuloma faciale.

This low-power histologic section shows a mixed infiltrate of lymphocytes, histiocytes, neutrophils, plasma cells, and eosinophils.

There is sparing of a narrow grenz zone between the inflammatory infiltrate and the overlying epidermis.

Question 3

Answer 3

Grannuloma Annulare

Palisading granulomatous inflammation surrounding degenerating collagen within the dermis.

Question 4

1. Identify the large cells in figure B
2. Diagnosis
3. Stain that can highlight lesional histiocytes

Answer 4

1. Touton giant cells
2. Juvenile xanthoganuloma
3. Lesional histiocytes are positive for stabilin-1

• Others: Cells stain for macrophage markers such as CD163, CD11b, CD11c, CD36, CD68, factor XIIIa, and vimentin.
• JXG can be distinguished from LCH by the expression of stabilin-1 and the absence of CD1a and CD207