NEURAL, FAT AND FIBROUS TUMOR Flashcards
1
Q
A
NEUROFIBROMA
- Not encapsulated
- Spindle cells with elongated, sometimes wavy nuclei
- Mast cells
- S100 positive
2
Q
A
Neurofibroma
3
Q
A
4
Q
A
5
Q
A
Schwannoma
6
Q
A
SMOOTH MUSCLE TUMOR: LEIOMYOMA
- Unencapsulated, intradermal tumor
- Interlacing and sometimes whorled bundles of smooth muscle cells
- Eosinophilic cytoplasm with blunt nuclear ends (cigar shaped)
- Special stain: Trichrome (red)
- IHC: Desmin
7
Q
Smooth muscle special stain
A
Trichrome Stain
8
Q
Smooth muscle IHC
A
Desmin
8
Q
A
9
Q
A
9
Q
A
ADIPOCYTIC TUMOR: FIBROLIPOMA
- Strands of collagenous, fibrous connective tissue within mature adipocytes
9
Q
A
10
Q
A
FIBROUS TUMOR: ANGIOFIBROMA
10
Q
A
FIBROUS TUMOR: HYPERTROPHIC SCAR
- Nodular, whorled masses
- More cellular than keloid
- Vertically aligned vessels
11
Q
A
FIBROUS TUMOR: HYPERTROPHIC SCAR
12
Q
A
13
Q
A
FIBROUS TUMOR: KELOID
14
Q
A
FIBROUS TUMOR: FIBROEPITHELIAL POLYP(ACROCHORDON)
- Epidermis: may be hyperplastic and papillomatous, surrounding core of fibrovascular tissue
- Loose fibrocollagenous stroma
15
Q
A
FIBROUS TUMOR: DERMATOFIBROMA (FIBROUS HISTIOCYTOMA)
- Hyperplastic epidermis with basal layer hyperpigmentation
- Rounding up of collagen bundles (collagen balls)
- Fibroblast-like spindle cells, histiocytes and blood vessels in varying proportions
- Factor XIIIa positive
17
Q
A
FIBROUS TUMOR: DERMATOFIBROMA
18
Q
A
19
Q
A
FIBROUS TUMOR: DERMATOFIBROSARCOMA PROTUBERANS
20
Q
- What is the diagnosis?
- Associated syndrome?
A
- Plexiform neurofibroma
- NF Type I
21
Q
- What is the diagnosis?
- IHC Stain?
A
Dermatofibroma
Factor XIIIa
22
Q
- What is the diagnosis?
- What is the area of highlighted cells called?
A
Schwannoma
Antoni B
23
Q
A
Leiomyoma
Masson’s Trichrome stain
24
Q
A
Neurofibroma
Mast cell
25
Q
A
ANGIOFIBROMA
Seen in:
-Tuberous sclerosis
-Fibrous papule of the face
-Pearly penile papules
27
Q
A
Keloid
