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DERMATOPATHOLOGY > PERIVASCULAR AND DIFFUSE DERMATITIS, NON-INFECTIOUS FOLLICULITIS AND PERIFOLLICULITIS > Flashcards

PERIVASCULAR AND DIFFUSE DERMATITIS, NON-INFECTIOUS FOLLICULITIS AND PERIFOLLICULITIS Flashcards

1
Q
A

URTICARIA

  • Sparse perivascular & interstitial infiltrate (LYMPHOCYTES, NEUTROPHILS,EOSINOPHILS)
  • +/- Dermal edema
  • Almost normal looking skin biopsy
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2
Q
A

PIGMENTED PURPURIC DERMATOSIS

  • Perivascular infiltrate composed of lymphocytes
  • Extravasated erythrocytes
  • Siderophages

Variable mild epidermal changes: Spongiosis, Lymphocyte exocytosis

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3
Q

What stain can be requested to highlight siderophages? What condition can this be seen?

A

Perl’s Stain
Pigmented Purpuric Dermatosis

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4
Q
A

POLYMORPHOUS LIGHT ERUPTION

  • Superficial and Deep
  • Lymphocyte predominant
  • Marked papillary edema
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5
Q
A

ARTHROPOD BITE HYPERSENSITIVITY

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6
Q
A

ERYTHEMA ANNULARE CENTRIFUGUM

  • Perivascular lymphohistiocytic infiltrate
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7
Q
A

POST-INFLAMMATORY PIGMENT ALTERATION

  • Normal looking epidermis
  • Mild Perivascular lymphohistiocytic infiltrate
  • Numerous Melanophages present in the superficial dermis
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8
Q
A

VITILIGO

  • Absence of melanocytes in the dermo-epidermal junction
  • Normal looking epidermis
  • Mild Perivascular lymphohistiocytic infiltrate
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9
Q

Normal melanocyte to keratinocyte ratio

A

1:4-1:10

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10
Q

Stains to highlight melanocyte

A

S100, SOX HMB-45, MART-1, Melan-A, MITF

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11
Q

Stains to highlight melanin

A

Fontana-Masson, Silver nitrate

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12
Q
A

TUMID LUPUS

  • Normal looking epidermis
  • Dense lymphohistiocytic infiltrate surrounding adnexa
  • Superficial and Deep Perivascular lymphohistiocytic infiltrate
  • Mucin highlighled by Alcian Blue
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13
Q
Marked papillary edema
A

SWEET’S SYNDROME

No fibrinoid degeneration or necrosis

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14
Q
Diffuse neutrophilic infiltrates, extensive suppuration
A

PYODERMA GANGRENOSUM

  • Fibrinoid deposition of blood vessels and Endothelial swelling
  • Follicular or perifollicular inflammation with micro-abscess formation
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15
Q
A

MASTOCYTOSIS – URTICARIA PIGMENTOSA

  • Loosely scattered or grouped mast cells in dermis
  • Basal hyperpigmentation
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16
Q
A

MASTOCYTOSIS - MASTOCYTOMA

  • Nodular to diffuse infiltrate of mast cells in upper dermis
  • Stain: CD117, c-kit, leder stain, giemsa, toluidine blue, tryptase
17
Q

Stains for mastocytoma

A

Stain: CD117, c-kit, leder stain, giemsa, toluidine blue, tryptase

18
Q
A

Terminal ANAGEN with glycogenated ORS & keratinized IRS

19
Q
A

CATAGEN follicles are notable by their eosinophilic “glassy” membrane & lack of a hair shaft

20
Q
A

TELOGEN follicle shows thick wrinkling bright eosinophilic keratin of IRS in the center

21
Q
A

ACNE VULGARIS

  • Suppurative folliculitis and Perifollicular infiltrates
  • Comedo - plug of corneocytes within a widened infundibulum
22
Q
A

ROSACEA - Erythemo-telangiectatic type

23
Q
A

ROSACEA - Erythemo-telangiectatic type

24
Q
A

Rosacea - Granulomatous type

25
Q

Scarring or non-scarring?

A

Scarring Alopecia

26
Q

what are the features of scarring alopecia

A
  • Loss of Sebaceous Glands
  • Presence of destructive inflammation or fibrosis around the follicles
  • Presence of compound follicles
27
Q

scarring or non-scarring?

A

NON-SCARRING ALOPECIA

  • Preserved Sebaceous Glands
  • Absence of destructive inflammation or fibrosis around the follicles
28
Q
A

ALOPECIA AREATA

29
Q
A

TRICHOTILLOMANIA

30
Q

Identify.
What condition is this seen?

A

Hamburger sign: vertically oriented split in the hair shaft containing proteinaceous material and erythrocytes

TRICHOTILLOMANIA

31
Q

What condition is this seen?

A

TRICHOTILLOMANIA

32
Q
A

ANDROGENETIC ALOPECIA

33
Q
A

LICHEN PLANOPILARIS

DERMATOPATHOLOGY (17 decks)

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