random Flashcards
Smudge cells, CD5,20,23, Older adults, lymphocytosis
CLL
Splenomeg. BCR-ABL, t9:22, granulocytosis
CML
Massive splenomeg., hairy cells, dry tap bone marrow
Hairy cell
Skin lesions (rash,plaques nodules), pautrier microabscesses, CD4+
Mycosis fungoides
LAD, CD4+, HLTV-1, skin lesions, hypercalcemia
ATLL
EPO low, Pruritus, increases RBC mass (hemoglobin, hematocrit), headaches, JAK2 mutation, splenomeg
PV
Thrombosis, bleeding, normal RBC and WBC count, ELEVATED platelets, JAK2 mutation
ET
JAK2 mutation, marrow fibrosis, leukoerythroblastic smear, tear drop RBC’s, Extramedullary hemato
Myelofibrosis
t14;18
follicular Bcl2
t14;11
Mantle cyclin d1
t14;8
Burkitts c-myc
Bone pain, M-spike (IgAorG), lytic bone lesions, bence jones proteins, CRAB
CRAB = hypercalcemia, Renal problems, Anemia, Bense Jones
Multiple myloma
M-spike, no CRAB, normal bone marrow
MGUS
No bone lesions, M-spike (IgM), headache, dizznesses, visual problems
Waldenstrom macroglbulinemia