HIV Flashcards
Zelda Lived Ten Daring Exciting AdventureS
(NRTI)
Zidovudine
Lamivudine
Tenofovir
Didanosine
Emtricitabine
Abacavir
Stavudine
Never Ever Delay (NNRTI)
Nevirapine
Efavirenz
Delavirdine
In the grave {Inte - grav (ir)}
Integrase inhibitors end in -gravir
Raltegravir
Elvitegravir
Dolutegravir
Bictegravir
Marry Enfuze at the door
Entry inhibitors
Maraviroc - gp120 binding blocker (CCR5 antagonist)
Enfuvirtide - gp41 binding
-navir never let the virus mature
Protease Inhibitors
Ritonavir
Lopinavir
Atazanavir
Darunavir
What does HAART mean
Highly Active Anti-Retroviral Therapy
First line treatments for HIV
PrEP (Pre-Exposure Prophylaxis)
-2NRTI : Tenofovir + Emtricitabine
PEP (Post Exposure Prophylaxis)
- 2NRTIs + 1 INSTI
Tenofovir + Emtricitabine + Dolutegravir
What causes HIV attachment
HIV gp120 binds to CD4 of T-cells and Macrophages
Coreceptor binding REQUIRED
-CCR5 (early infection) -M-topic
-CXCR4 (late infection) - T-tropic
NRTI MOA
Acts as nucleoside/-tide analog and binds to active site of RT
Requires phosphorylation
COMPETITIVE INHIBITORS
NNRTIs MOA
Directly allosterically binds to RT
Doesnt require phosp.
Integrase Inhibitors MOA
Bind to INtegrase enzyme, thus stopping integration
Protease Inhibitors MOA
Binds to protease enzyme, thus stopping protein cleavage
NRTI side effects
Mitochondrial toxicity, peripheral neuropathy, BM suppression, lactic acidosis, lipodystrophy
Didanosine- pancreaDIDIS
Zidovudine- anemia, agranucytosis
Abacavir - inc rish of CAD
Tenofovir-nephrotoxic
NNRT side effects
Liver toxicity, Jaundice, SJS (severe rash), teratogenic
Efavirenz- vivid dreams
Integrase Inhibitors side effects
InCKreases Creatine Kinase, rhabdomyolysis (myopathy)
Protease Inhibitor side effects
Lipodystrophy, Hyperglycemia (insulin resistant), GI problems, Dyslipidemia
Indinavir- problems INDI-kidney
Ritonavir- Inhibits p450 (dont give with rifampin)
