Cancer Drugs Flashcards
Antimetabolites (Pyrimidine syn)
Methotrexate–>DHFR
5-FU–> pyri. analong—> inhibits thymidylate synthase
Hydroxyurea—> Ribonucleotide reductase–> no deoxy pyrimi.
S phase
Antimetabolite (Purine syn)
Azathioprine + 6-mercaptopurine—>HGPRT
Mycophenolate mofetil—> no GMP
S phase
Antimetabolite (DNA pol. inhibitors
Cladribine–>Purine analog
Cytarabine—>pyrimidine analog
Gemcitabine –>pyrimidine analog
-bine ending
S phase
Alkylating Agents
Cyclophosphamide
Nitrosoureas (-mustin/streptozotozin)
Busulfan
all cause DNA strand crosslinking
Platins
All cause DNA crosslinking
contain platinum
Cisplatin
Carboplatin
Oxaliplatin
Cytotoxic Drugs
Bleomycin–>free radical gen.–>dmg’s DNA
Doxorubicin–> free radical gen. + DNA intercalation (G-C)
Actinomycin D–> DNA Intercalation (A-T)
Common toxicities of anthracyclines
Dilated cardiomyopathy
Common toxicities of bleomycin
Pulmonary toxicities
Common toxicities of cisplatin
Nephrotoxicity
ototoxicity
peripheral neuropathy
Common toxicities of Cyclophosphamide
Hemorrhagic cystitis
Renal cancer
Common toxicities of paclitaxel
Peripheral neuropathy
Common toxicities of vincristine/vinblastine
Peripheral neuropathy
What drugs inhibit vit K carboxylation
Warfarin
What drugs increase antithrombin III activity
Heparin
What drugs directly bing to factor Xa
Apixaban
Rivaroxaban
What does the med PCC stand for
Prothrombin complex concentration
What reverses Heparin
protamine sulfate
What reverses walfarin
PCC and Vit K injection
What reverses apixaban
Andexanet (Modified Factor Xa) and PCC
Rituximab MOA
MOA: Targets CD20 on B-cells, inducing cell lysis.
Cetuximab MOA
MOA: EGFR-targeting monoclonal antibody.
Bevacizumab
MOA: Inhibits VEGF, preventing angiogenesis.
Alemtuzumab
MOA: Targets CD52 on B and T lymphocytes, depleting immune cells.
Trastuzumab
MOA: Binds HER2/neu receptor, preventing receptor activation.
treats breast cancer
cardiotoxic
Erlotinib
MOA: EGFR tyrosine kinase inhibitor.
Sunitinib
MOA: Inhibits multiple receptor tyrosine kinases, including VEGFR, PDGFR, and c-Kit.
Sorafenib
MOA: Inhibits RAF, VEGFR, and PDGFR, interfering with tumor growth and angiogenesis.
Vemurafenib
MOA: Inhibits BRAF V600E mutation in melanoma.
what treats hairy cell leukemia
Cladribine
What treats APL
ATRA
what treats CML
imatib
What treats follicular lymphoma
rituximab
What type of vasculitis present with recurrent oral and genital ulcers, uveitis and POSITIVE pathergy test?
Behcets syndrome
