Ramachandran Angles and Protein Structures

Question 1

Which amino acid has the most restricted Ramachandran plot?

Answer 1

Proline

Question 2

What amino has the least restricted Ramachandran plot?

Answer 2

Glycine

Question 3

What are the major protein structures?

Answer 3

The alpha helix and beta strand

Question 4

What is the structure of myoglobin?

Answer 4

• An all alpha soluble protein containing 8 alpha helices

- Also contains a heme group

Question 5

What is the structure of carboxypeptidase A?

Answer 5

Consists of a central mixed beta sheet surrounded by alpha helices

Question 6

What is the principal protein in mammalian hair, nails, and skin?

Answer 6

Alpha keratin

Question 7

What is the psuedo-repeat sequence of keratin?

Answer 7

A-b-c-d-e-f-g, with nonpolar residues at a and d

Question 8

What is the most common vertebrate protein?

Answer 8

Collagen

Question 9

What consists of Type I collagen?

Answer 9

• Two a1 and one a2 chain
• Repeat of Gly-Pro-Hyp (hydroxyproline)
• a Gly at every third position in the chain makes it possible to bring the chains very close together

Question 10

True or False. Proteins have not evolved to be optimally stable, they have evolved to be optimally functional.

Answer 10

True

Question 11

What are some popular protein denaturants?

Answer 11

• Heat
• Guanidinium chloride
• Urea