Citric Acid Cycle

Question 1

How many ATPs are produced by oxidation of Acetyl CoA in the Citric Acid Cycle?

Answer 1

10 ATPs

Question 2

How many NADHs are produced from the TCA cycle?

Answer 2

3

Question 3

How many FADHs are produced from TCA cycle?

Answer 3

1

Question 4

Where is the TCA cycle occuring?

Answer 4

In the mitochondrial matrix

Question 5

What steps in TCA are regulated?

Answer 5

1, 3, 4

Question 6

What enzyme(s) in the TCA cycle are involved in oxidative carboxylation?

Answer 6

isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase

Question 7

What enzyme is prochiral?

Answer 7

Citrate

Question 8

All but 1 enzyme in the TCA cycle sit inside the mitochondrial matrix. What is the enzyme?

Answer 8

Succinate dehydrogenase

Question 9

What enzyme produces an ATP/GTP in the TCA cycle?

Answer 9

Succinyl-CoA synthase

Question 10

true or false - Mg2+ and Ca2+ activate conversion of pyruvate to acetyl CoA

Answer 10

true

Question 11

true or false - insulin does not activate conversion of pyruvate to acetyl CoA

Answer 11

false

Question 12

what others molecules activate conversion of pyruvate to acetyl CoA?

Answer 12

ADP, pyruvate

Question 13

what molecules inhibit the conversion of pyruvate to acetyl CoA?

Answer 13

Acetyl-CoA, NADH, ATP

Question 14

What is a cataplerotic process?

Answer 14

It depletes intermediates

Question 15

What is a anaplerotic process?

Answer 15

It builds up intermediates

Question 16

What is the role of the malate-aspartate shuttle?

Answer 16

it exchanges cytosolic NADH for mitochondrial NADH

Question 17

What is the role of the glycerophosphate shuttle?

Answer 17

Takes e- from cytosolic NADH into the ETC (loss of energy)

Question 18

what is the role of citrate synthase?

Answer 18

attach 2 C from acetyl-CoA onto oxaloacetate (4c) to form citrate (6c)