Rabies Flashcards
Rabies virus is a member of the family Rhabdoviridae. Two genera-in this family,, contain species that causehuman disease
Lyssavirus and Vesiculovirus
causes vesiculation and ulceration in cattle, horses,and other animals and causes a self-limited, mild, systemic illness inhumans
vesiculoviru
The incubation period of rabies (defined as the interval between exposure and the onset of clinical disease) is usually
20–90 days, but in rare cases is either as short as a few days or >1 year.
are prominently infected in Rabies; infection of astrocytes is unusual
Neurons
What are The 3P’s which are earliest specific neurologic symptoms of rabie? one or more of which occur in 50–80% of patients and strongly suggest rabies.
paresthesias
pain
pruritus near the site ofthe exposure
Early brainstem cardinal features of encephalitic rabies
hyperexcitability
hydrophobia
aerophobia
In Prodomal features, The wound has usually healed by this point,and these symptoms probably reflect infection with associated inflammatory changes in
local dorsal root or cranial sensory ganglia
Encephalitic rabies is distinguished by
EARLY BRAINSTEM INVOLVEMENT
True or false:
Antibodies may be detected within a few days after the onset of symptoms, but some patients die without detectable antibodies.
True
True or false:
RIG should not be administered to previously vaccinated persons.
True
True or false:
Rabies vaccine and RIG should never be administered at the samesite or with the same syringe.
True
True or false:
Pregnancy is contraindication to PEP VACCINE
False
1-mL doses of rabies vaccine Should be given IM in the___ area. (The anterolateral aspect of the thigh also is acceptable in children.)
deltoid
If human RIG is unavailable, purified equine RIG can be used inthe same manner at a dose of
40 IU/kg
