Lupus Nephritis

Question 1

The most common clinical sign of renal disease is

Answer 1

proteinuria

Question 2

is the only reliable method of identifying the morphologic variants of lupus nephritis

Answer 2

renal biopsy

Question 3

What class of lupus nephritis describes normal glomerular histology by any technique or normal light microscopy with minimal mesangial deposits on immunofluorescent or electron microscopy

Answer 3

Class 1 minimal mesangial

Question 4

What class designates mesangial immunecomplexes with mesangial proliferation with expansion of the mesangial matrix

Answer 4

Class II

Mesangial proliferation

Question 5

What class esions are typically associated with minimal renal manifestation and normal renal function; where “nephrotic syndrome” is rare. Patients with lesions limited to-the renal mesangium have an excellent prognosis and generally do not-need therapy for their lupus nephritis

Answer 5

Class I and class II

Question 6

describes focal lesions with proliferation or scarring, often involving only a segment of the glomerulus and have the most varied course

Answer 6

Class III

Focal nephritis

Question 7

describes global“diffuse” proliferative lesions involving the vast majority-of glomeruli Patients commonly have high antiDNA antibody titers, low serum complement, hematuria, red bloodcell casts, proteinuria, hypertension, and decreased renal function; 50%of patients have nephrotic-range proteinuria. Without treatment, this aggressive lesion has the “Worst renal prognosis”

Answer 7

Class IV

Diffuse nephritis

Question 8

lesion describes subepithelial immune deposits producing a “membranous pattern”; a subcategory is associatedwith proliferative lesions and is sometimes called “mixed” membranous-and proliferative disease

Answer 8

class V 
Membranous nEphritis

Question 9

lesions have >90% sclerotic glomeruli and ESRD with interstitial fibrosis. Global sclerosis of nearly allglomerular capillaries

Answer 9

Class VI

Sclerotic nephritis