Rabies

Question 1

Rabies virus pathogenesis

Answer 1

Enters through skin wound or mucosal surfaces
Replicates in muscles and neuromuscular junction and will move into CNS
Can incubate for 3 months or in rare cases a year

Question 2

Rabies treatment

Answer 2

*Vaccination: hot lasts 2 years and takes 2 weeks after shot to grow immunity. *PEP - antibodies from vaccinated blood donors, provides passive immunity

Question 3

Rabies Baltimore

Answer 3

-ssRNA brings polymerase with it to make mRNA

Question 4

Rabies Virion

Answer 4

M-matrix
G-glycoprotein, receptor binding 
P- polymerase phosphoprotein
N-nucleocapsid
L-RdRp

Question 5

Rabies entry

Answer 5

receptor is nAchR, travels retrograde towards CNS so uses dyenin motor protein.
will eventually kill neuron b/c disrupts cell trafficking

Question 6

Rabies clinical

Answer 6

by the time symptoms appear its too late. hydrophobia, treatment is supportive not cured