Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Virology > HIV > Flashcards

HIV Flashcards

1
Q

HIV Baltimore

A

RNA reverse transcribing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

HIV genome

A
  • hybridized into tRNA, t-RNA a single strand of RNA and makes a DNA copy
  • RNA is a primer to make new DNA by using the new DNA from tRNA as a template.
  • RNA is completely used up, there will be two DNA strands.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

properties of RT

A 
primer
free 3'hydroxyl
rna>dna template
dNTPs
DNA synthesis slow and error prone bc no proofreading
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

HIV nucleocapsid

A 
2 copies of +ssRNA 
reverse transcriptase
Protease 
Integrase
brings MHC and ICAM-1 (cell adhesion) with them
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

retroviral genes

A

Gag-matrix and nucleocapsid proteins
Pol-
Env- Gp120, Gp40

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Gp120

A

binds to CD4 receptor on host cell and causes conformational change.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Gp41

A

binds to CCR5 or CXCR4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Reverse transcriptas

A

copies +ssRNA into dsDNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Integrase

A

allows viral DNA to be integraded into host cell’s DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Protease

A

breaks long chainlike molecules of protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Gag

A

determines retroviral core

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pol

A

reverse transcriptase, RNase H, and integrase functions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Env

A

envelope protein, resides in lipid layer and determines viral tropism.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ART Antiviral Retro Theory

A

is a cocktail of drugs that target multiple factors such as viral fusion, RT, Integrase, Protease, viral assembly, and viral regulatory factors. The pill they take daily.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

limitation of the control mechanisms for HIV

A

Cannot stop primary infection, cannot get off daily drugs. Must use ART Therapy and PREP to prevent exposre.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

replication

A

no DNA and no RNA replication in the HIV lifecycle.

17
Q

HIV transmission

A

anal or vaginal intercourse, sharing needles, blood transfusions, congential AIDS.

18
Q

HIV infection

A
  • CCR5 binding strain to dendritic cells and the DC cells takes the virus to lymph nodes.
  • Active replication is in lymphoid tissue.
  • High levels of viremia and down-regulation of replication by immune response.
19
Q

vaccine for HIV

A

not possible
mimic natural immunity and HIV kills immune cells
vaccines are for stable viruses and HIV mutates
no animal models to study

Virology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions