Polio

Question 1

Polio Baltimore

Answer 1

+ssRNA

in cytoplasm, can make proteins right away

Question 2

Polio virion

Answer 2

non-enveloped, icosahedral resistant to a lot

Question 3

Polio capsid and genome

Answer 3

VP1,2,3,4

monocistronic (single open reading frame) can easily make mRNA for proteins

Question 4

Polio attachment and entry

Answer 4

enters via endocytosis in pyers patches and tonsils. attach via CD155
VP1 and 4 form a pore in host membrane and RNA is released into cytoplasm

Question 5

polio exit

Answer 5

lyses the host cell

Question 6

polio transmission and disease

Answer 6

fecal-oral oral-oral

mostly asymptomatic sometimes mild, sometime paralysis

Question 7

Polio VPg

Answer 7

Attaches to the 5’ end of a positive strand of RNA and acts a primer for viral synthesis.

Question 8

VP1

Answer 8

part of the poliovirus capsid combines with VP4 form a pore in host membrane and RNA is released into cytoplasm

Question 9

VP4

Answer 9

inner surface of the capsid.

combines with VP1 to form a pore in host membrane and RNA is released into cytoplasm

Question 10

viremia

Answer 10

blood infection leading to infection of CNS

Question 11

Polio treatment

Answer 11

vaccines