Rabia

Question 1

Which of the following is not associated with the invasive and metastasis ability of tumor cells?

a) Type 4 Collagenase
b) Matrix Metalloproteinase
c) Telomeras
d) Katepsin D
e) E-Kadherin

Answer 1

c) Telomeras

Question 2

Which one of the following is an indirect carcinogenic found in smoking and involved in the development of bronchial carcinoma?

a) Polisiclic aromatic hydrocarbons
b) Vinyl chloride
c) Nitrosamid
d) Cyclophosphamide
e) Aflatoxin

Answer 2

a) Polisiclic aromatic hydrocarbons

Question 3

Which tumor causes the most frequent cancer death in women?

a) Lung cancer
b) Ovarian cancer
c) Pancreatic cancer
d) Breast cancer
e) Colon cancer

Answer 3

a) Lung cancer

Question 4

Which tumor is characterized by t(9:22) and BCR-ABL1 activation?

a) Burkitt lymphoma
b) Follicular lymphoma

C) Ewing’s sarcoma

d) Mantle cell lymphoma
e) KML

Answer 4

e) KML

Question 5

Which of the following is not the property of the anaplastic cell?

a) Loss of polarization
b) Atypical mitosis

C) Nuclear pleomorphism

d) Decrease in the number of mitosis
e) Nuclear hyperchromasis

Answer 5

d) Decrease in the number of mitosis

Question 6

Which one plays a role in the development of nasopharynx carcinoma?

a) HHV8
b) HBV

C) HCV

d) EBV
e) HTLV1

Answer 6

d) EBV

Question 7

Which one of the molecule that stops the external apopitosis by blocking kaspas-8?

a) BCL2
b) MSH2

C) BAX

d) BRCA1
e) P53

Answer 7

a) BCL2

Question 8

What is the name of the spread of tumor cells through blood, lymphatic and body cavities?

a) Anaplasia
b) invasion
c) Neoplasia
d) Metastas
e) Displasia

Answer 8

d) Metastas

Question 9

Which disease is often accompanied by osteosarcoma?

a) Ataxia telangiectasia
b) Retinoblastoma
c) X-related lymphoproliferative syndrome
d) Xeroderma pigmentosum
e) Herediter non-polyposis colon cancer syndrome

Answer 9

b) Retinoblastoma

Question 10

Which of the following is not characteristic of cancer?

a) Limited replication potential
b) Angiogenesis
c) invasive ness and metastasis ability
d) It’s self-sufficient for growth signals
e) Getting rid of the immune system

Answer 10

a) Limited replication potential

Question 11

Which one of the following gene is associated with breast and ovarian tumors?

a) NF1
b) BRCA1

C) MSH1

d) P16
e) TP53

Answer 11

b) BRCA1

Question 12

Which of the following does not detect DNA repair damage?

a) Bloom syndrome
b) Fanconi anemia

C) Xeroderma pigmentosum

d) Ataxia telangiectasia
e) Neurofibromatosis type 1

Answer 12

e) Neurofibromatosis type 1

Question 13

Which of the following is the definition of benign epithelial neoplasms that form finger-like protrusions from the epithelial surface macroscopically or microscopically?

a) Cystadenoma
b) Adenoma

C) Hamartoma

d) Choristoma
e) Papilloma

Answer 13

e) Papilloma

Question 14

Which one isn’t Paraneoplastic Syndrome?

a) Malignant Melenoma
b) Migratuar Tromboflebit
c) DIC
d) Acanthosis nigricans
e) Hypertrophic osteoarthropathy

Answer 14

a) Malignant Melenoma

Question 15

Which tumor marker-tumor mapping is wrong..

Answer 15

PSA-pancreatic cancer

Question 16

Which one of the following is not tumor supressor gene

Answer 16

BCR-ABL

Question 17

Erbb2(Her2 Neu) overactivity occurs in which of the following

Answer 17

breast cancer

Question 18

‘Produced in a cell and effects the neighboring cell to stimulate proliferation’ what effect does the sentence define the growth factor

Answer 18

Paracrine effect

Question 19

Which congenital impairment in the ps53 gene, which one of the following develops

Answer 19

LiFraumeni syndrome

Question 20

Which one/ones below is not/ are not true description of invasion?

I- Monitoring of adenocarcinoma, spilling over colon serosa, in uterus serosa

II- Determination of infiltrative carcinoma, monitored in breast, in ipsilateral axillary lymp node.

Ill-Determination of squamous cell carcinomal monitered in lung, in costa bone.

Answer 20

II-III