Genetic

Question 1

Which of the following is not one of the Phase II metabolizing enzymes:

a) NATS
b) TPMTS

C) CYP450

d) GSTS
e) UGTS

Answer 1

C) CYP450

Question 2

Which of the following is TRUE?

I-According to Knudson two hit hypothesis: cancer develops after second mutation of the gene.

II-Common mutations in hereditary breast and over cancer are BRCA1/2.

III-Hereditary nonpolyposis colorectal cancer develops due to mutations of mismatch repair genes.

Answer 2

I-II-III

Question 3

Which of the following is not one of the antibody diversity mechanisms?

a) Somatic hypermutations
b) Junctional diversity

C) Somatic recombination

d) Combinations of receptor chains
e) Locus heterogeneity

Answer 3

e) Locus heterogeneity

Question 4

Which of the following is not one of the advantages of pharmacogenetics?

a) improving efficacy and patient compliance
b) predicting a patient’s response to drugs

C) developing “customized” prescriptions

d) minimizing or eliminating adverse events
e) confidentiality.use,storage of genetic information

Answer 4

e) confidentiality.use,storage of genetic information

Question 5

Which of the following is TRUE?

I-class I MHC proteins are encoded by HLA-A, HLA-B, HLA-C genes.

II-class II MHC proteins are encoded by HLA-DP, DQ and DR genes

III-Application of HLA in medicine is important in transplantation.

Answer 5

I-II-III

Question 6

Which of the following is TRUE?

I-Cancer develops due to gain of function mutations of oncogenes.

Il-Cancer develops due to loss of function mutations of tumor suppressor genes.

III-Cancer develops through an accumulation of somatic mutations.

Answer 6

I-Il-III

Question 7

I-Hereditary nonpolyposis colorectal cancers develops due to mutations of mismatch repair genes

II-Cancer develops due to loss of function mutations of tumor suppressor genes.

III-Somatic hypermutation is one of the antibody diversity mechanisms.

IV-Pharmacogenetics is the basis of precision medicine

Choose true ones.

Answer 7

I-II-III-IV

Question 8

Which of the following is NOT true?

A) Pharmacogenetics, help determining appropriate dosing.avoiding unnecessary toxic treatments.

B) Oncogenes are genes that, when mutated, fail to repress cell division

C) Somatic mutation is the basis for the development and progression of all types of cancer.

D) Applications of HLA in medicine are transplantation, forensic medicine, regulating immune responses.

E) Class I MHC antigens are; HLA-A, HLA-B and HLA-C

Answer 8

B) Oncogenes are genes that, when mutated, fail to repress cell division

Question 9

which of the following is not true..

pharmacogenetics provides choosing novel treatment according to the patient’s wishes

Answer 9

pharmacogenetics provides choosing novel treatment according to the patient’s wishes

Question 10

which of the following is not one of the phase 2 metabolizing enzymes….

CYP

Answer 10

CYP