Rabbit GI System Flashcards

1
Q

What is the Digestive Physiology of Rabbits?

A
  • Herbivorous
  • GI system combines simple stomach w/ hindgut cecal fermentation
    • Transit time ~3-6hrs
  • Dietary fiber stimulates gut motility
  • Teeth developed for high-fiber diet
    • Chewing w/ 120 jaw movements/min w/ lateral motion
  • Peristalsis propels high fiber particles through colon quickly ⇢ firm pellets
  • Fine low fiber particles travel backwards from colon to cecum
  • In the cecum, small particles and fluid ⇢ fermentation ⇢ volatile FA, etc
    • This fermentation vat is where millions of gut bacteria digest the indigestible
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2
Q

Describe the GI anatomy of rabbits?

A
  • Large abdominal cavity
  • GI tract is long (10-20% BW)
  • Stomach contains 15% of the ingesta
  • Cardia and pylorus well developed
    • Unable to vomit
  • Pylorus easily compressed by duodenum
  • Small intestines are 12% of GI volume
  • Ileum ends at cecum, where it is expanded (sacculus rotundus)
  • Large, thin-walled cecum holds ≥40% of ingesta
    • Most prominent organ of abdominal cavity
    • Sacculations and bands
    • Contains Bacterioides, protozoa, and some Clostrium, etc
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3
Q

What does the diet of a rabbit consist of

A
  • Fiber (≥15-16% CF) promotes motility
    • Provides large particle size ⇢ lattice-like ball ⇢ permits gastric acid penetration and digestion
  • Pelleted diet (13-18% crude protein)
  • Feed:
    • Premium high fiber hay (>70%)
    • High fiver uniform pellet (<25%)
    • Fresh greens (<5%) daily
    • Treats (<5%) - low sugar, high fiber treats (several times a week)
    • Fresh clean water
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4
Q

What are Cecotrophs?

A
  • Specialized fecal pellets produced in cecum
  • Contain 2x protein, ⇡ volatile FA, ⇡ B vitamins, and ⇣fiber of usual fecal pellets
  • Cecotrophy is particularly important for efficient digestion of forage protiens
  • pH of stomach is <2.0 which may neutralize bacterial ingested with cecotrophs
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5
Q

What would High energy, low fiber diets lead to in rabbits?

A
  • Increase susceptibility to mucoid enteropathy and other enteric diseases
  • Low-fiber:
    • ⇣ intestinal motility
    • Prolong cecal retention time
    • Reduce feed intake
    • Predispose to diarrhea
    • May change normal flora
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6
Q

What do high fiber diets do for rabbits?

A
  • Stimulate normal digestion, absorption, peristalsis and excretion
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7
Q

What are the problems High Carbohydrate diets may cause in rabbits?

A
  • Excessive glucose allow Clostridium spp. and E. coli to proliferate
  • Results in excess VFA’s ⇢ lower cecal pH ⇢ inhibits normal flora ⇢ proliferation of pathogens ⇢ production of gas and toxins
  • High carb diets inhibit release of motilin ⇢ further slowing GI motility
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8
Q

What changes occur in the GI pH when rabbits mature?

A
  • Gastric pH changes from 5.0-6.5 in neonate to 1.0-1.9 weanling/adults
    • bunnies can take probiotics
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9
Q

What are the functions of the gut microorganisms in rabbits?

A
  • Contains bacteria, some yeast, fungi, and protazoa
  • Provides capability to digest food items (energy)
  • Some bacteria may confer some immunity
  • Management can influence the multibiome
    • Need to know which external factors can have adverse affect on gut flora
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10
Q

What Grass Hays are fed to rabbits

A
  • Timothy
    • Most popular and readily available in pet stores
    • long strand fiber source
    • Low in protein, calcium, and energy
    • Harvested 2-3 times a year depending on climate
  • Orchard
    • Nutritionally similar to timothy
    • Soft texture w/ sweet smell and taste
    • High palatability to many small herbivores
  • Oat
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11
Q

What is Alfalfa?

A
  • Legume family, not a grass
  • Higher protein, calcium, and energy
  • Feeding Recommendations:
    • young, growing animals
    • Treat in adult animals
    • Appetite stimulant in senior animals
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12
Q

What is hay fiber?

A
  • Hays made up of 2 types of fiber:
    • Indigestible fiber (larger particles) for proper gut motility
    • Digestible (fermentable) fiber (smaller particles) provides essential nutrients for cecum and for normal bacterial flora
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13
Q

What are the Psychological Benefits of Hay?

A
  • Encourages natural behaviors
    • Stimulates foraging and grazing
  • Mentally stimulating
    • Decreases boredom-based negative behaviors
  • Increases activity
  • Provides sense of security
  • A Pet that lives an enriched life is healthier, happier pet
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14
Q

What are causes of Rabbit Gastrointestinal Syndrome? (RGIS)

A
  • Low-fiber diet
  • Small pyloric sphincter
  • Inability to vomit
  • Myoelectrical initiation of peristalsis occurs in duodenum or jejunum
  • Excessive grooming
  • dehydration
  • Stress
  • Pain
  • Disease
  • GI blockage
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15
Q

What are the clinical signs of RGIS

A
  • Gut stasis
    • can be panful and potentially fatal
    • Interstitial fluid flows into gut ⇢ dehydration
    • Reduction in absorption of electrolytes ⇢ electrolyte derangement
  • Anorexia
  • Oligodipsia
  • Production of very small (or no) fecal pellets (rarely diarrhea)
  • Depression +/-
  • Weight loss +/-
  • Pain (hunched over, tooth grinding, abdominal tenderness)
  • abnormal intestinal sounds
  • Acute Pyloric obstruction ⇢ depression, bloating (intensely painful), dehydration, hypothermia, shock
  • Death - accompanied by hepatic lipidosis +/- clostridial overgrowth
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16
Q

How does RGIS progress?

A
  1. Low fiber diet/stress/disease
  2. ⇣ GI motility
  3. Inappetence
  4. Imbalance of cecal flora/dehydration
  5. Overgrowth of Clostridium spp
  6. Gas and toxin production
  7. GI tract pain
  8. ⇣⇣ motility/anorexia
  9. Hepatic damage/lipidosis
  10. Death
17
Q

How is RGIS diagnosed?

A
  • History
  • Clinical signs
  • Physical examination
  • Radiography
  • CBC/serum chemistries
  • Exploratory laparatomy (seldom indicated)
18
Q

What does the Body Temperature of a rabbit indicate during RGIS?

A
  • With onset of shock, rabbits become hypothermic, bradycardic, and hypotensive
    • Always obtain a BT in suspect cases
  • BT of 98-99F are in early stages of shock
  • BT below 98F indicate severe life-threatening shock
19
Q

What is the treatment of RGIS?

A
  • Most respond to aggressive medical management
  • Rehydration (PO, SC, IV)
    • Maintenance fluids is ~ 100-120 ml/kg/day
    • Administering 50-60ml/kg/day SC generally adequate in combination w/PO fluids
      • 25-35 ml/kg warm fluids may be needed q8h
    • Oral electrolytes generally required as well
    • Critically ill patients will require IV fluids
    • Important to rehydrate gastric contents
    • Balanced electrolyte solutions (unsweetened Pedialyte), water
  • Force-Feeding ~10-15ml/kg q6-8h of Critical Care for Herbivores or Blenderized rabbit pellets in electrolyte solution (Pedialyte)
    • or as much as they will comfortably take
    • NG tube may be indicated
    • Fresh greens and timothy or grass hay ad libitum
  • Vitamin B Complex (0.02-0.4 ml/rabbit SC, IMq24h)
  • Antibiotics, if indicated
    • Enrofloxacin (5-10 mg/kg PO, SC [if diluted] q12h)
    • TMS
    • Metronidazole (20mg/kg PO q12hr for 3-5days)
    • Use parenterally until stools are passed
  • Analgesics
    • Meloxicam (1mg/kg SC, IM PO q24h)
    • Buprenorphine (0.01-0.05 mg/kg SC,, IM, IV q6-12h)
    • Butorphanol (0.1-0.5 mg/kg SC, IM IV q4h)
    • Simethicone (65-130 mg/animal PO q1h for 2-3 doses) for abdominal discomfort
  • Gastrointestinal promotility agents
    • Metoclopramide (0.2-0.5 mg/kg PO, SC q6-8h)
    • Cisapride (0.5mg/kg PO q8-12hh) compounded
  • Adsorbents - Cholestramine
  • May need to prevent gastric ulceration
    • Cimetidine (5-10mg/kg PO, SC, IM, IV q6-12h)
    • Ranitidine (2mg/kg IV q24h or 2-5 mg/kg PO q12h)
  • Midazolam (0,25-0.5mg/kg SC, IM, IV) to reduce anxiety
    • may also stimulate appetite
  • Exercise and abdominal massage
  • Thermal support if Temp ≤99F
  • Grooming
20
Q

What surgical treatments are there for RGIS

A
  • Decompression of the stomach w/ an 18-French red-rubber catheter as an orogastric tube
  • Gastrotomy if unresponsive to medical therapy
  • Guarded prognosis (hepatic lipidosis +/-)