Ferrets and Ferret Diseases Flashcards

1
Q

What are the current uses of Ferrets

A
  • Laying and testing cables
  • Ferret-legging for entertainment
  • Fur production - fitch ferrets
  • laboratory animals
  • Pets
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2
Q

What animal and human diseases have been tested using ferret models

A
  • Canine distemper virus
  • Human Influenza virus
  • Reye’s syndrome
  • Cardiovascular disease
  • Helicobacter-associated gastritis and ulceration
  • Lawsonia/Campylobacter enteritis
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3
Q

How do Ferrets reproduce? litter size? etc

A
  • Seasonally polyestrus
    • Breeding season: March to August
    • Induced ovulators
      • stay in estrus until ovulation
  • Sexually mature 8-12mo
  • Gestation: 41-42 days
  • Litter size: 6-10
  • Weaning: 6-8 weeks
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4
Q

Why do Ferrets smell? (Body odor)

A
  • Source:
    • anal gland secretions (minimal contribution)
    • sebaceous gland secretions (major)
  • Strongest: intact males
    • removal of anal glands + castration = reduced smell, but sebaceous glands impart majority
  • Do NOT bathe to reduce smell
    • harmful to fur coat and skin
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5
Q

What should the diet of Ferrets consist of?

A
  • Obligate Carnivores
  • Crude Protein: 30-35%
  • Fat content: 15-20%
    • No kitten food - too high in fat
  • High quality ferret food w/ animal-based dietary protein
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6
Q

How should Ferrets be handled/restrained

A
  • Ideal:
    • place one hand under or around the chest
    • lift and support hind limbs w/ other hand
    • Hold ferret close to body for security and stability
  • Scruffing should only be done when absolution necessary
    • ~50% of ferrets will yawn when scruffed
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7
Q

What are the basic physiological parameters of Ferrets?

A
  • Temp: 100-103
  • HR: 180-320 bpm
  • RR: 20-60 brpm
  • BW: 600-2000g
    • males larger
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8
Q

What is the normal posture of a ferret?

A
  • Walk with a normal hump in back
  • Weak or ill ferret will lose normal hump in back, rear limb weakness and ataxia
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9
Q

What are the unique things about the Cardiovascular system in Ferrets?

A
  • Heart more caudal 6-8th ribs
  • Dramatic respiratory sinus arrhythmia is normal
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10
Q

What are some unique PE findings for ferrets

A
  • Middle-aged to older usually have a dramatically enlarged spleen
    • usually benign (extramedullary hematopoiesis)
  • Lymph nodes surrounded by fat
    • do not mistake for enlargement
    • firmness or asymmetry ⇢ lymphadenopathy
  • Adrenocortical disease common
    • look for alopecia (especially flanks, shoulders, tail base)
    • look for vulvar swelling or reddening of the prepuce
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11
Q

What vaccines should ferrets receive

A
  • Rabies
    • Imrab licensed for ferrets
    • killed vaccine
  • Canine Distemper virus
    • canarypox-vectored recombinant
    • only CDV licensed for ferrets
  • Consider antihistamine as premedication for vaccine reaction
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12
Q

What is the shock organ of ferrets?

A
  • GI tract
  • Vaccine reaction may present as severe diarrhea or vomiting
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13
Q

What is the vaccination schedule for ferrets

A
  • Young ferrets (<14 wks of age)
    • serial distemper vaccines every 4 wks until 14wks of age
      • 6, 10 14 or 8, 12, 16
    • Rabies at 3 months
  • Adults:
    • Yearly distemper
      • initial series 2 vaccines 3 wks apart
    • Yearly rabies vaccine
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14
Q

What is Ferret insulinoma?

A
  • Pancreatic beta cell tumor
  • Affects middle-aged to older pet ferrets
  • Results: low blood glucose levels in the face of high insulin levels
  • Common clinical signs:
    • depression
    • star-gazing
    • posterior paresis/ataxia
    • nausea (hypersalivation, pawing at mouth)
    • seizure
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15
Q

What is Ferret Adrenal Gland Disease?

A
  • Very common - no true cure
  • Early spay/neuter practice may play role
    • Diet
    • UVB exposure
  • Common Clinical Signs:
    • Alopecia
    • vulvar enlargement
    • prostatic inflammation
    • pruritus
    • aggression
  • Pathology: Hyperplasia ⇢ adenoma ⇢ carcinoma
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16
Q

What is Ferret lymphoma

A
  • Various forms seen depending on age
    • Juvenile form - respiratory distress secondary to thymic enlargement (<3 years of age)
    • Adult onset - peripheral lymphadenopathy
  • No conclusive evidence on treatment or long term prognosis
17
Q

What is Ferret Helicobacter Gastritis?

A
  • Helicobacter mustelae
  • Colonizes GIT in nearly 100% of ferrets shortly after weaning
  • Reported in any age - infection increases in severity as ferret ages
  • Often asymptomatic, but can overgrow w/ stress or concurrent disease ⇢ gastritis, gastroduodenal ulcers
  • Clinical signs: most subclinical
    • Vomiting
    • nausea
    • abdominal pain
    • ptyalism
    • pawing at mouth
    • bruxism
    • diarrhea progressing to melena
      • acute and chronic onset reported
18
Q

How is Ferret Helicobacter Gastritis Diagnosed/Treated

A
  • Diagnosis: often presumptive
    • definitive - gastroscopy w/ biopsy
      • Warthin-Starry silver stain
    • Hard to culture
    • PCR
  • Treatment: combo therapy more effective
    • Metronidazole + bismuth + amoxicillin
19
Q

What human disease can affect ferrets?

A
  • Human influenza virus
    • Transmission:
      • ferret to ferret
      • ferret to human
      • human to ferret
  • COVID
20
Q

How does Human Influenza virus affect Ferrets?

A
  • Clinical signs:
    • Fever
    • Upper respiratory tract illness
      • coughing, sneezing, thick nasal discharge, water eye)
    • Lethargy
    • Anorexia
    • Vomiting
    • Diarrhea
  • Most adults recover w/in 7-14 days w/ supportive care
  • Worse in very old and very young ferrets
21
Q

How does COVID affect Ferrets?

A
  • Reported clinical signs:
    • Gastroenteritis
    • severe lethargy
    • dehydration
    • respirator signs
      • coughing, sneezing
22
Q

Where can blood samples be taken from ferrets?

A
  • Cranial Vena Cava - best
    • just lateral of the manubrium ad cranial to the first rib
  • Jugular vein
  • Cephalic vein - small volumes only
  • Lateral saphenous vein
    • small volmes only
23
Q

What is unique about the clinical pathology of Ferrets?

A
  • Normal Hematocrit relatively high (46-61%)
    • dramatically decreased with the use of isoflurane or sevoflurane
      • max effect 15 minutes; duration 45 minutes)
  • Normal Creatinine levels relatively low
    • 0.1-0.3 mg/dL almost always <0.5mg/dL