RA (TsDMARDS) Flashcards
what are the target-specific non-biologic DMARDs?
- tofacitinib
- upadacitinib
- baricitinib
What is the MOA of the tsDMARDS (non biologics)
Janus associated kinase inhibitor
what is the onset of Tofacitinib?
2 weeks
what are the ADRs of Tofacitinib?
- infection
- diarrhea
- nausea
- headache
what are the warnings of Tofacitinib?
- bone marrow suppression
- decreased HR
- GI perforation
- hepatotoxic
what to monitor when taking Tofacitinib?
- CBC
- LFTs
- sCr
- lipids
- hepatitis
- TB
what is the BBW of Tofacitinib? (Oral drug)
- serious infection
- lymphoma and other malignancies
- thrombosis
- increased all cause mortality
- TB
what are the ADRs of Upadacitinib?
- URTI
- neutropenia
- nausea
- thrombosis
- increased lipids
what is the dose of Upadacitinib? PO
Daily
What to monitor for Upadacitinib?
- CBC
- LFT
- Lipids
What are the BBW of Upadacitinib?
- Serious infection
- Malignancies
- Thrombosis
What are the ADRS of Baricitinib
- URTI
- Nausea
- Thrombosis
- Increased LFTs
- Lipids
What to monitor for Baricitinib
- CBC
- LFTs
- Lipids
What are the BBW of Baricitinib
- Serious infections
- Malignancies
- Thrombosis
can a patient take both Methotrexate and tofacitinib?
Yes
can a patient take both Tofacitinib and baracitinib?
No
*no tsDMARDS (biologics) together
can a patient take Methotrexate, leflunomide, sulfasalazine, hydroxychloroquine and tofacitinib?
Yes
can 2 bDMARDs be used together?
No
can a JAK inhibitor and bDMARD be used together?
No
