RA - Schellhase Flashcards
Corticosteroid AE - Short Term
hyperglycemia
gastritis
mood changes
elevated BP
Corticosteroid AE - Long term
aseptic necrosis
cataracts
obesity
growth failure
osteoporosis
monitoring parameters - corticosteroids
baseline: BP, BG
maint: BP, BG (q3-6m)
MTX dosing
2.5mg tablet strength
7.5mg weekly (po or IM)
-can go up to 15-20mg
onset: 1-2 months
MTX AE
bone marrow supp.*
NVD*
mucositis*
cirrhosis
fibrosis
alopecia
rash
teratogenic
*prescribe 1mg/day of folic acid to reduce sx
MTX monitoring
CXR
CBC
SCr
LFT
Albumin
HCQ monitoring/counseling
vision exam
take w food
no myelosupp.
anakinra monitoring
neutrophil count
abatacept warnings
do not use with TNF or IL-1
increased risk of infection
no live vaccines while using
caution in COPD pts
malignancy risk
IL-6 warnings
serious infections
CI: liver toxicity, thrombocytopenia, neutropenia
lipid abnormalities
IL-6 monitoring
neutrophils
platelet
lfts
lipids
RA classes (conventional synthetic DMARDs)
MTX
SSZ
HCQ
leflunomide
RA classes (biologic DMARDs)
TNF neutralizers
-etanercept
-infliximab
-adalimumab
-golimumab
-certolizumab
*additional
-anakinra
-abatacept
IL-6 inh.
-tocilizumab
-sarilumab
anti-CD20 Ab
-rituximab
RA classes (targeted synthetic DMARDs)
JAKs
-tofacitinib
-baricitinib
-upadacitinib
