Exam 2 - supportive care 1

Question 1

types of NV

Answer 1

anticipatory
acute
delayed
breakthrough
refractory

Question 2

reason for targeting 5HT3 and NK1 for NV

Answer 2

they are in the stomach which then crosses to chemo receptor zone

Question 3

chemoreceptor trigger zone contains what receptors

Answer 3

5HT, D2, M, H1, NK1

Question 4

H1, ACh

Answer 4

refractory

Question 5

5HT, substance P

Answer 5

most used, most regimens have these

Question 6

single agent level 5 emesis

Answer 6

single drug with >90% frequency of emesis

Question 7

single agent level 3-4 emesis

Answer 7

single drug with 30-90% frequency of emesis

Question 8

single agent level 2 emesis

Answer 8

10-30%

Question 9

single agent level 1 emesis

Answer 9

<10%

Question 10

oral chemo agents are what level emetogenic potential

Answer 10

low to moderate 10-30%

Question 11

highly emetogenic regimen A

Answer 11

NK-1 antagonist
steroid
5HT3 antagonist
atypical antipsychotic

Question 12

highly emetogenic regimen

Answer 12

atypical antipsych: olanzapine
5HT: palonosetron
steroid: dex

Question 13

highly emetogenic regimen

Answer 13

NK1
steroid: dex
5HT

Question 14

moderately emetogenic regimen A

Answer 14

steroid
5HT

Question 15

moderately emetogenic regimen B

Answer 15

olanzapine
palonosetron
dexamethasone

Question 16

moderately emetogenic regimen C

Answer 16

Nk1
steroid
5HT3

Question 17

low emetogenic regimen
-pick any one of these

Answer 17

dexamethasone
metoclopramide
prochlorperazine
dolasetron
granisetron
ondansetron

Question 18

NK1 antagonist options

Answer 18

aprepitant oral
-injection
fosaprepitant IV
rolaprepitant oral
netupitant/palonsetron
fosnetupitant/palonosetron

Question 19

steroid options

Answer 19

dexamethasone

Question 20

5HT3 antagonist options

Answer 20

dolasetron
granisetron
ondansetron
palonosetron

Question 21

atypical antipsychotic options

Answer 21

olanzapine

Question 22

two drug classes you can add to any antiemetic regimen

Answer 22

benzodiazepine
PPI

Question 23

breakthrough NV regimen
-pick 1

Answer 23

haloperidol
metoclopramide
prochlorperazine
promethazine
olanzapine
lorazepam
dronabinol
nabilone
dolasetron
granisetron
ondansetron
dexamethasone
scopolamine

Question 24

if pt shows delayed NV after chemo initially, give antiemetics then chemo
-agents include:

Answer 24

dex
NK1
olanzapine

Question 25

common toxicities in 5HT class

Answer 25

HA (switch to other 5HT)
constipation (add bowel regimen)

Question 26

common toxicities in steroids class

Answer 26

hyperglycemia
increased appetite

Question 27

common toxicities in substance P antagonists class

Answer 27

hiccups (change drug or treat hiccups)

Question 28

common toxicities in dopamine antagonists class

Answer 28

diarrhea (DC drug)

Question 29

atypical antipsychotics

Answer 29

sedation