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Antimicrobials / Immune-Related > RA/Migraine Agents > Flashcards

RA/Migraine Agents Flashcards

1
Q

Methotrexalate

A

Antimetabolite
MOA: inhibits AICAR transformylase -> ↑ extraceullar adenosine and ↓ T-cell activation

Rx: 1st line Tx for RA

SE: lymphocyte toxicity

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2
Q

Leflunomide

A

MOA: inhibits ribonucleotide synthesis -> cell cycle arrest

Rx: 1st line Tx for RA

Both symptomatic improvement and retardation of structural joint damage

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3
Q

Chlorquine

A

Antimalarial Agent

MOA: unclear (anti-inflammation)

Rx: RA

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4
Q

Hydroxychloroquine

A

Antimalarial Agent

MOA: unclear (anti-inflammation)

Rx: RA

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5
Q

Etanercept

A

Anti-TNF Agent
MOA: cytokine receptor fusion protein

Rx: RA

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6
Q

Infliximab

A

Anti-TNF Agent

MOA: anti-TNF chimeric monoclonal ab

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7
Q

Anakinra

A

IL-1 Inhibitor
MOA: IL-1 cytokine receptor decoy

Rx: RA

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8
Q

Propanolol

A

Beta Blocker
MOA: decreased vasodilation

Rx: Migraine prevention

SE: tiredness

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9
Q

Metoprolol

A

Beta Blocker
MOA: decreased vasodilation

Rx: Migraine prevention

SE: tiredness

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10
Q

Amitryptyline

A

TCA

Rx: Migraine prevention

SE: drowsiness

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11
Q

Valproic Acid

A

Anticonvulsant

Rx: Migraine prevention

SE: drowsiness, tetratogenicity

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12
Q

Topiramate

A

Anticonvulsant

Rx: Migraine prevention

SE: drowsiness, tetratogenicity

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13
Q

Metoclopramide

A

Antiemetic
MOA: D2 antagonist / 5-HT3 antagonist

Rx: N/V of acute migraine attack

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14
Q

Chlorpromazine

A

Antiemetic
MOA: D2 antagonist

Rx: N/V of acute migraine attack

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15
Q

Prochlorperazine

A

Antiemetic
MOA: D2 antagonist

Rx: N/V of acute migraine attack

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16
Q

Ergotamine

A

Ergot Derivative
MOA: Vasoconsriction via 5-HT(1D) receptor acivation

Rx: acute migraine attack

Caution w/ CV dz

17
Q

Dihydroergotamine

A

Ergot Derivative
MOA: Vasoconsriction via 5-HT(1D) receptor acivation

Rx: acute migraine attack

Caution w/ CV dz

18
Q

Sumatriptan

A

Triptan
MOA: vasoconstriction via 5-HT(1D) and 5-HT(1B)

Rx: acute migraine attack

Antimicrobials / Immune-Related (9 decks)

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