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Antimicrobials / Immune-Related > NSAIDs / Gout > Flashcards

NSAIDs / Gout Flashcards

1
Q

Aspirin

A

NSAID
Acetylsalicylic Acid

MOA: irreversible COX inhibitor

Low dose: analgesic, antipyretic
High dose: anti-inflammatory

SE: prolongs bleeding time, upset GI (PUD)

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2
Q

Salicylic Acid

A

NSAID

MOA: reversible COX inhibitor

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3
Q

Ibuprofen

A

NSAID

MOA: nonselective COX inhibitor

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4
Q

Indomethacin

A

NSAID

MOA: nonselective COX inhibitor

Rx: severe gout and ankylosing spondylities

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5
Q

Ketorolac

A

NSAID

MOA: nonselective COX inhibitor

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6
Q

Naproxen

A

NSAID

MOA: nonselective COX inhibitor

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7
Q

Oxaprozin

A

NSAID

MOA: nonselective COX inhibitor

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8
Q

Piroxicam

A

NSAID

MOA: nonselective COX inhibitor

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9
Q

Sulindac

A

NSAID

MOA: nonselective COX inhibitor

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10
Q

Celecoxib

A

NSAID

MOA: COX-2 selective inhibitor
(analgesic, antipyretic, anti-inflammatory)

SE: CV thrombotic events

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11
Q

Acetaminophen

A

Not an NSAID
Analgesic/Antipyretic only

MOA: unclear

Rx: frequently used in children and elderly

SE: hepatotoxicity

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12
Q

Colchicine

A

Rx: acute gout Tx
MOA: ↓ pain and inflammation (inhibits leukocyte migration and phagocytosis)

SE: severe diarrhea

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13
Q

Allopurinol

A

Xanthine Oxidase inhibitor
MOA: blocks conversion of xanthine -> uric acid

Rx: in b/w gout attacks

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14
Q

Febuxostat

A

Xanthine Oxidase inhibitor
MOA: blocks conversion of xanthine -> uric acid

Rx: allopurinol intolerance

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15
Q

Probenecid

A

Uricosuric
MOA: inhibits tubular absorption of uric acid -> ↑ renal clearance

Gout prophylaxis only

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16
Q

Sulfinpyrazone

A

Uricosuric
MOA: inhibits tubular absorption of uric acid -> ↑ renal clearance

Gout prophylaxis only

17
Q

Etoricoxib

A

NSAID

MOA: COX-2 selective inhibitor
(analgesic, antipyretic, anti-inflammatory)

SE: CV thrombotic events

18
Q

Meloxicam

A

NSAID

MOA: COX-2 selective inhibitor
(analgesic, antipyretic, anti-inflammatory)

SE: CV thrombotic events

Antimicrobials / Immune-Related (9 decks)

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