RA - L4 Flashcards
1
Q
Patterns of Bone Loss in RA
A
juxta-articular osteopenia
focal bone erosion
systemic osteoporosis
2
Q
Where does RANKL come from?
A
osteoblasts synovial fibroblasts (additional source) T cells (additional source)
3
Q
What are the cells responsible for bone erosion in RA?
A
osteoclasts ONLY
4
Q
What is OPG.Fc treatment?
A
increase in OPG expression
decreased bone erosion
5
Q
What cytokines promotes osteoclast differentiation directly?
A
RANKL
IL-1
TNF
6
Q
What cytokines promotes osteoclast differentiation indirectly?
A
TNF
IL-6
IL-1
IL-17