BC - L6

Question 1

Topics?

Answer 1

origin of self-reactive lymphocytes
mechanism for removing self-reactive lymphocytes
potential causes of autoimmune disease
categories of disease types
SLE
B cell based therapies

Question 2

What triggers tolerance?

Answer 2

too high affinity with self in the absence of additional information

Question 3

Describe the mechanism for removing self reactive lymphocytes

Answer 3

-

Question 4

Evidence for tolerance?

Answer 4

-

Question 5

Why does strong binding lead to deletion in some cases but immune response in others?

Answer 5

-

Question 6

How does tolerance silence self-reactives?

Answer 6

deletion

non-responiseveness/Anergy

Question 7

What are some caveats in tolerance? Causes of autoimmune?

Answer 7

not all self-antigens are in the bone marrow, spatially and temporally
B cells need a degree of self-reactivity to signal successful rearrangement and
indeed to signal for continued survival
self-reactive B cells may encounter their antigen in an inflammatory context

Question 8

What are the categories of autoimmune based on?

Answer 8

specificity
contribution of Abs
role of innate immune cells
SYSTEMIC or LOCAL

Question 9

Categories of B cell involvement?

Answer 9

autoantibodies
immune complexes
antigen presentation & co-stimulation
lymphoid organogenesis

Question 10

Describe SLE (aetiology, pathogenesis)

Answer 10

-

Question 11

Describe Rituximab

Answer 11

-

Question 12

SLE therapies?

Answer 12

Belimumab

Bortezomib