ND - L1 Flashcards
Classic view to study disease
make a model explain pathogenesis histology biochemistry phenotype
Disease elements
risk factors
disease onset
active disease
failed organ
Parkinson’s progression of understanding
Parkinsonism substantia nigra cell loss Lewy bodies dopamine a-synuclein a-synuclein primary component of Lewy bodies
Relate the disease elements to PD
? + genes
disturbance in a-syn causing LBs
loss of midbrain neurons, causing loss of dopamine transmission
motor symptoms of PD
What is the MND SOD1 observation about?
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Why do clinical signs matter?
beginning of understanding process:
Clinical signs of late PD
sleep disorder autonomic failure motor signs dementia impulsivity neuro-psychiatry
What are the main elements of PD pathology?
substantia nigra cell loss
Lewy bodies
a-syn
What is the SNs location & function? What are its two parts?
midbrain, forms part of basal ganglia controls voluntary movement, produces dopamine pars compacta (pigmented), pars reticulata (unpigmented)
Where does the SN connect to?
striatum
What does the striatum do?
panning & modulting movement
Describe a-syn
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Describe a-syn pathway
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What can modulate the aggregation of a-syn?
genetics
dopamine (how?)..
iron, oxidants, environmental toxins can increase aggregation
What are the two theories for the spread of a-syn?
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