R 3.9 Transplant immunology Flashcards
Xenographic transplants only have issues with the _____ immune response.
MHC-II/CD4+
The difference in timeline of rejection for hyperacute, acute, and chronic are ____, _____, and _____.
6 months
An acute humoral response will take up to ______ compared to a an acute cellular response which takes _____.
4-7 days; 48 hours
In chronic rejection, the loss of peripheral tolerance is driven by _____ T cells and antibody production.
MHC-II/CD4+
After peripheral tolerance is lost, ______ in chronic rejection.
MHC-I/CD8+
In graft vs host, there is no hyper acute response because there are no ______ _____ in donor tissue.
pre-existing antibodies
Central tolerance involves self-reactive T and B cells being ____ in the thymus/bone marrow.
deleted
If a donor had the alleles (A2, A2), the recipient must also have the alleles (___, A4).
A2
If the host had the alleles (A2, A4) and the donor had the alleles (A2, A3), the transplant ____ work.
wouldn’t
Elimination of donor _____ cells prior to transplant reduces rejection in the case of MHC-II.
dendritic
Granzymes and perforins will cause cell ____ in MHC-I response.
death
MHC-II requires local tissue _____ for antigen presentation.
damage
NK cells recognize lack of proper _____ on cells.
MHC-I
When a graft rejects a host, the immune response is more ___ compared to when a host rejects a graft.
systemic
