R 3.10 Pharmacology of Transplant

Question 1

____ and _____ are calcineurin inhibitors that prevent the expression of IL-2 to prevent T-cell proliferation and are metabolized by CYP3A4.

Answer 1

Cyclosporine; Tacrolimus

Question 2

mTOR inhibitors ____ and ____ bind to FKBP work to prevent IL-2 signaling and have no nephrotoxicity.

Answer 2

Sirolimus; Everolimus

Question 3

_____ inhibits de novo synthesis of nucleotides and ____ inhibits the conversion of inosoine monophosphate to xanthosine monophosphate.

Answer 3

Azthioprine; Mycophenolate mofetil

Question 4

Antibody based therapy such as _______ and ______ work by removing CD3 presenting cells and inhibiting IL-2.

Answer 4

Muromonab; Basiliximab

Question 5

For induction therapy, the categories of drugs that you need to give are….

Answer 5

Calcineurin inhibitors, corticosteroids, and antimetabolites

Question 6

For maintenance therapy, the common combination used is?

Answer 6

Tacrolimus, mycophenolate, mofetil, and prednisone