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OLD "MIC 665" > Quiz 5 > Flashcards

Quiz 5 Flashcards

1
Q

The gut immune system doesn’t respond with inflammation but antigen-specific _____________

A

tolerance

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2
Q

What cell aid in tolerance?

A

Tregs

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3
Q

What are the 3 non-inflamamtory/tolerant cytokines that direct DCs?

A

retinoid acid
TSLP
TGF-B

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4
Q

Lymphocytes are primed in _________________ of the mucosal tissue

A

inductive compartments

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4
Q

What are the inductive compartments of the gut?

A

peyer’s patch
ILF
mesenteric lymph nodes

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5
Q

What chemokine recruits naive T cells to the inductive compartments?

A

CCR7

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6
Q

What does CCR7 on lymphocytes recognize?

A

CCL21

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7
Q

What highly expressed CCL21?

A

HEV on inductive sites

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8
Q

What makes entering the MALT v. peripheral lymph nodes is what?

A

adhesion receptors

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9
Q

L-PAM-1 expressed by T cells that recognizes ___________ expressed on endothelium mucosal

A

MAdCAM-1

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10
Q

Can DCs express CCR7 like T cells?

A

yes

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11
Q

Effector T cells squeeze through inflamed endothelial cells. What causes the inflamamtion?

A

IL-1B

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12
Q

What controls the exit of activated effector T cells from T cell zone?

A

S1P gradient

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13
Q

Is S1PR highly expressed on naive or effector T cells?

A

effector

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14
Q

What does S1PR allow T cells to do?

A

see the S1P gradient and leave the lymphatics

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15
Q

What expresses S1P?

A

endothelial cells of lymph nodes

16
Q

What creates the graident of S1P?

A

stromal cells that produce S1P lyase

17
Q

Where is the S1P gradient to strongest and weakest?

A

strong: efferent vessels
weak: T cell zone

18
Q

If T cells are not activated by thier antigen in the T cell zone they upregulate _______ on them

A

CD69

19
Q

What does CD69 do when highly expressed on T cells?

A

helps sequester and internalize S1PR, keeping T cell inside the lymph nodes
* cannot see S1P gradient anymore

20
Q

Activated effector T cells have what 2 fates?

A
  1. return to lamina propria
  2. migrate to intraepithelial compartment

** both rely on chemokines

21
Q

Small intestines express CCL___ which is recognized by CCR__ on T cells

A

CCL25
CCR9

22
Q

Large intestines express CCL___ which is recognized by CCR__ and GPR___ on T cells

A

CCL 28
CCR10 and GPR15

23
Q

Lungs/skin express CCL___ which is recognized by CCR__ on T cells

A

CCL17
CCR4

24
Q

TFH cells up regulate _______ which allows them to leave T cell zone and migrate to B cell follicles

A

CXCR5

25
Q

_______ is produced by stromal cells in the B cell follicle and attracts T cells

A

CXCL13

26
Q

CD103 interacts with ______________ to aid in intraepithelial lymphocyte trafficking

A

E-cadherins

27
Q

What does E-cadherins do?

A

expressed below adherens junctions on intestinal epithelial cells to allow intraepithelial lymphocytes to reside between epithelial cells

OLD "MIC 665" (5 decks)

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