Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

OLD "MIC 665" > Quiz 2 > Flashcards

Quiz 2 Flashcards

1
Q

What is the systemic immune system made of?

A

Bone marrow
Spleen
Lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pathogen enters —> DC takes up antigen —> DC migrates to nearest lymph node —> DC presents to T cell —> T cell activates and goes into circulation

What is the inductive site?

A

Lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pathogen enters —> DC takes up antigen —> DC migrates to nearest lymph node —> DC presents to T cell —> T cell activates and goes into circulation

What is the effector site?

A

Infected tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Was the systemic or mucosal immune system discovered first?

A

Systemic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is special about mucosal inductive sites?

A

They lack afferent lymphatics because they sample antigens directly from mucosal surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the 4 types of MALT?

A

GALT (gut)
NALT (nasal)
BALT (bronchus)
TALT (tear-duct)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the GALT made up of?

A

Peyer’s patch
Isolated lymphoid follicles (ILF)
Appendix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What MALT is MLN (mesentric lymph nodes) associated with?

A

GALT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are MLN (mesentric lymph nodes)?

A

Draining lymph nods of GALT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the NALT made up of?

A

Waldeyer’s ring (adenoid and palatine tonsils)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are CLN (cervical lymph nodes)?

A

Draining lymph nodes of NALT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What MALT is typically not found in adults?

A

BALT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are effective sites?

A

Where effector cells perform thier action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What’s are the 3 effector sites of the mucosal immune system?

A

Lamina propria
Surface epithelium
Stroma of exocrine glands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are some examples of innate immune cells?

A

macrophages
DC
Granulocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are some examples of adaptive immune cells?

A

All B and T cells
Plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Where are most innate immune cells located in mucosal immunity?

A

Lamina propria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are some of the cell types in Peyer’s patch?

A

Macrophages
DC
Naive T cells
Naive B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

In systemic immunity, __________ act as the cellular messengers by delivering degraded pathogens to lymphoid organs

A

Dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which of the following is most likely to be found in the inductive compartment of the GALT?

Naive T cells
Effector CD4+ T cells
Eosinophils
Plasma cells
Innate lymphoid cells

A

Naive CD4+ T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What kinds of cells are found in inductive sites?

A

APCs
Naive B and T cells

22
Q

What does the NALT drain into?

A

Cervical lymph nodes

23
Q

What are the 2 primary lymphoid tissues?

A

Thymus
Bone marrow

24
Q

What are primary lymphoid tissues?

A

Site of lymphocyte development

25
Q

What are the 3 secondary lymphoid tissues?

A

Spleen
Lymph nodes
MALT (Peyer’s patch, ILT, spleen)

26
Q

What are secondary lymphoid tissues?

A

Induction of adaptive immune response

27
Q

What allows enter of fluids and lymphocytes unto lymph nodes?

A

Lymphatic capillaries (afferent vessel)

28
Q

When fluid/lyphocytes enter the lymph nodes via afferent vessels where does it go next?

A

Outer cortex (contains germinal centers)

29
Q

Where do DCs go to present to T cells in the lymph nodes?

A

Paracritical area

30
Q

How do lymphocytes leave the lymph nodes?

A

Efferent vessels

31
Q

How do lymphocytes enter the Peyer’s patch?

A

Across endothelial venues on M cells (no afferent vessels)

32
Q

How do lymphocytes leave the Peyer’s patch?

A

Efferent vessels

33
Q

T/F lymph nodes and Peyer’s patch both contain DCs that present antigens to T cells in T cell areas

A

True

34
Q

T/F lymph nodes and Peyer’s patch both have B cell follicles where T cells can active naive B cells

A

True

35
Q

T/F lymph nodes and Peyer’s patch both have germinal centers that give rise to plasma cells

A

True

36
Q

T/F lymph nodes and Peyer’s patch both allow naive lymphocytes in via high endothelial venules from circulation

A

True

37
Q

T/F lymph nodes and Peyer’s patch both allow activated lymphocytes to leave via efferent lymphatics

A

True

38
Q

T/F lymph nodes and Peyer’s patch both have afferent lymphatics

A

False (only lymph nodes have afferent)

39
Q

T/F lymph nodes and Peyer’s patch both have efferent lymphatics

A

True

40
Q

T/F lymph nodes and Peyer’s patch both sample antigens directly from mucosal surface

A

False Peyer’s patch only does this

41
Q

Does vascular diameter increase or decrease in inflammatory response and why?

A

Increase = more blood flow

42
Q

Does permeability increase or decrease in the inflammatory response?

A

Increase

43
Q

Why does adhesion receptors increase expression on endothelial cells during inflammatory response?

A

Tells lymphocytes where to go

44
Q

What does clotting increase during the inflammatory response?

A

Stop spread of infection

45
Q

What 2 things cause tissue damage during inflammatory response?

A

Fluid leaking
Influx of immune cells

46
Q

Systemic immunity inflammatory response is _________ while mucosal immunity inflammatory response is _________ to invading microbes

A

Reactionary
Proactive

47
Q

Why does the mucosal immune system use a proactive response to invading microbes?

A

Constant exposure to microbes

48
Q

What is the most important thing to maintain in mucosal immunity?

A

Barrier integrity

49
Q

Why is it important to maintain the barrier integrity of the mucosal immune system?

A

Fluid leakage between two different compartments can cause complications and tissue damage

50
Q

What mechanisms does the mucosal membrane use in the proactive approach?

A

Thick mucus and IgA to prevent microbes from ever reaching the epithelium

51
Q

______ are important in preventing epithelial damage because they deliver antigens past the epithelial layer to Peyer’s patch

A

M cells

OLD "MIC 665" (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions