Quiz 3

Question 1

What organ is responsible for metabolism in the “first pass effect”?

a) liver
b) heart
c) gallbladder
d) kidneys

Answer 1

A

Question 1

Acidic drugs, such as phenytoin, bind primarily to which of the following plasma proteins?

a) a1-fetoprotein (AFP)
b) GC Globulin
c) Albumin
d) a1-acidic glycoprotein (AAG)

Answer 1

C

Question 2

Basic drugs, such as lidocaine, bind primarily to which of the following plasma proteins?

a) a1-fetoprotein (AFP)
b) GC-Globulin (GCG)
d) albumin
d) a1-acid glycoprotein (AAG)

Answer 2

D

Question 3

Warfarin is a CYP-450 2C9 substrate and sulfamethoxazole/trimethoprim is 2C9 inhibitor. Which of the following effects would be expected if the drugs were coadministered?

a) decreased warfarin effect
b) increased warfarin effect
c) increased sulfamethoxazole/trimethoprim effect
d) decreased sulfamethoxazole/trimethoprim effect
e) no change in effect

Answer 3

B