Quiz 2

Question 1

Superfamily of receptors that normally reside inside the cell in the cytoplasm or nucleus:

a) ligand-gated ion channels

b) G-proteins coupled receptors

c) kinase-linked and related receptors

d) steroid receptors

Answer 1

D

Question 2

Following the agonist activation of a single G-protein coupled receptor, amplification of the downstream signal occurs because:

a) heterogeneity of g-proteins allows different signals in different tissues

b) duration of activation of G-protein is longer than agonist activation of receptor

c) the receptor is internalized

d) fast sodium channels close

Answer 2

B

Question 3

The physico-chemical properties that most likely explains a drug’s ability to bind to several different subtypes of adrenergic receptors is:

a) weak acid is ionized at physiologic pH

b) multiple stereoisomers arise from multiple chiral carbons in the drug’s structure

c) high degree of lipophilicity

d) high degree of hydrophilicity

Answer 3

B

Question 4

Among the following drug types, which would most likely bind to a different site from the agonist:

a) partial agonist
b) inverse agonist
c) competitive antagonist
d) allosteric agonist

Answer 4

D

Question 5

Among the following receptors, which has only one transmembrane spanning domain in its resting (not activated) state?

a) androgen receptor
b) histamine (H1) receptor
c) insulin receptor
d) nicotinic acetylcholine receptor

Answer 5

C