Quiz #2 (endocrine) prep Flashcards
What physiologic effect does cortisol have on protein metabolism?
incr protein synthesis in the lives and decr protein synthesis in muscle, lymphoid tissue, adipose tissue, skin, and bone; incr plasma levels of amino acids.
What physiologic effect does cortisol have on carbohydrate metabolism?
diminish uptake and utilization of glucose,
incr output of glucose from the liver,
enhances the elevation of blood glucose promoted by other hormones.
What physiologic effect does cortisol have on lipid metabolism?
breakdown of fat in the extremities (lipolysis)
production of fat in face and trunk (lipogenesis)
What physiologic effect does cortisol have on inflammation?
inhibits fibroblast proliferation and function at inflammatory site and accounts for poor wound healing, incr susceptibility to infection, and decr inflammatory response with chronic glucocorticoid excess.
What physiologic effect does cortisol have on digestive function?
promotes gastric secretion
What physiologic effect does cortisol have on urinary function?
enhances urinary excretion
What physiologic effect does cortisol have on connective tissue function?
decr proliferation of fibroblast in connective tissue
What physiologic effect does cortisol have on muscle function?
skeletal and cardiac muscle maintains normal contractibility and max work output
What physiologic effect does cortisol have on bone function?
decr bone formation
What physiologic effect does cortisol have on vascular system and myocardial function?
maintains normal BP, incr responsiveness of arterioles for constrictive action of adrenergic stimulation; optimizes cardiac performance.
What physiologic effect does cortisol have on CNS function?
modulates perceptual and emotional functioning (mechanism is unknown)
What are the levels of corticoidsteroid-induced myopathy?
advanced - difficult climbing stairs
high - cannot rise from chair
intermediate - cannot walk with out assistance
low - cannot elevate extremities or move in bed
What are some clinical findings of cushings syndrome?
central and generalized obesity, dorsal kyphosis, moon (round) face, hirsutism (hair growth), enlarged supraclavicular fat pats buffalo hump, muscle weakness, osteoporosis
What are 3 causes of hyperthyroidism?
graves disease (autoimmune)
nodular goiter
thyroid adenomas
What cardiovascular and pulmonary effects will you see in a patient with hyperthyroidism?
incr. HR, cardiac output, blood volume, RR
dysrhythmias (Afib)
weakness in respiratory muscles (breathlessness)
