Quiz 2 Flashcards
All of the Cells in the Hematopoietic System develop from what cell in the bone marrow?
The pluripotent hematopoietic stem cell
What are the main cells of the lymphatic system?
T and B cells are the main cells of the lymphatic system
What is the function of T & B cells?
The function of T cells and B cells is to recognize specific “non-self” antigens, during a process known as antigen presentation
What is a controlled substance?
Controlled substances are drugs that have some potential for abuse or dependence
FDA regulates Controlled Substances
Name the Schedule for controlled substances
Schedule I: drugs with no currently accepted medical use and a high potential for abuse
Schedule II: drugs with a high potential for abuse; less than Schedule I drugs
Schedule III: drugs with a moderate to low potential for physical and psychological dependence
Schedule IV; drugs with a low potential for abuse and low risk of dependence
Schedule V: drugs with lower potential for abuse than Schedule IV
Schedule I for controlled substances, with examples
Schedule I: drugs with no currently accepted medical use and a high potential for abuse
- Most dangerous of all drug schedules w/ potentially severe psychological and/or physical dependence
Ex: Heroin, Ecstasy, LSD
Schedule II for controlled substances, with examples
Schedule II: drugs with a high potential for abuse; less than Schedule I drugs
- Can potentially lead to severe psychological or physical dependence and are also considered dangerous
ex: Morphine & Fentanyl , Oxycodone (OxyContin), Adderall and Ritalin (used for ADHD)
Morphine & Fentanyl
Oxycodone (OxyContin)
Adderall and Ritalin
Schedule II
Schedule III for controlled substances, with examples
Schedule III: drugs with a moderate to low potential for physical and psychological dependence
- abuse potential is less than that of Schedule I & II drugs but greater than Schedule IV drugs
ex: Ketamine, Anabolic steroids –Testosterone, Marijuana (cannabis)
Schedule IV for controlled substances, with examples
Schedule IV; drugs with a low potential for abuse and low risk of dependence
ex: Xanax, Valium, Ambien
Schedule V for controlled substances, with examples
Schedule V: drugs with lower potential for abuse than Schedule IV
- containing limited quantities of certain narcotics
- generally used for antidiarrheal, antitussive, and analgesic purpose
ex: Lomotil, Lyrica, Cough medicine
What are Adverse effects/reactions (ADRs)
- Any undesirable action - side effects - that can include
Undesirable effects, many of which
can be tolerated
These are generally reversible upon
drug discontinuation
They are dose related - Toxicity reactions
Resulting in cell and tissue damage
Permanent and generally intolerable
Factors that increase the risk of ADR are reactions
Increasing age of the child
Increasing number of drugs
Oncological treatment
ADRs Symptoms for Nervous System Name 3
Dizziness
Drowsiness
Depression
Delusions
Confusion
Headaches
ADRs Symptoms for eyes name 3
Eyelids & Conjunctiva are frequent targets for drug toxicity
Blurred/double vision
Increased Ocular Pressure
Damage to the retina and optic nerve
Erythema multiforme
Stevens-Johnson Syndrome: (Erythema multiforme in its most severe form)
ADRs Symptoms for Auditory-vetibular system
Dizziness
Vertigo
Other balance disorders
Hearing loss
Tinnitus
-Tinnitus and dizziness are the most common side effects of medications
What are the most common side effects of ADR for Auditory-vetibular system
Tinnitus and dizziness are the most common side effects of medications
ADRs Symptoms for SKIN
Acne
Alopecia
Herpes simplex
Sweating
Urticaria (hives)
What is an antigen?
antigen - a substance that elicits an immune response
What are the Immune System Components
Antigen-Specific
Systemic
Memory
Self/non-Self recognition
what Recognize and act against particular antigens
Antigen-Specific:
Antigen Specific
Immune System Component
Antigen-Specific: Recognize and act against particular antigens
Systemic
Immune System Component
Systemic: Not Confined to the initial infection but work throughout the body
Memory
Immune System Component
Memory : Recognizes and mounts an even stronger attack to the same antigen next time
Builds immunity; Vaccinations or Cold/flu
Self/Non-Self Recognition
Most Important Component of the immune system
Self/non-self recognition is achieved by every cell displaying a marker based on the major histocompatibility complex (MHC)
- MCH are group of genes that code for cell surface proteins essential for the immune system
Any cell not displaying this marker is treated as non-self and attacked
What is Not Confined to the initial infection but work throughout the body
Systemic
What Recognizes and mounts an even stronger attack to the same antigen next time
Memory
What is Achieved by every cell displaying a marker based on the major histocompatibility complex (MHC); Any cell not displaying this marker is treated as non-self and attacked
Self/Non-Self Recognition
autoimmune disease & examples
Sometimes the process breaks down and the immune system attacks the body’s own cell
Ex: multiple sclerosis (MS), sudden sensorineural hearing loss (SSNHL), rheumatoid arthritis
Sometimes the process breaks down and the immune system attacks the body’s own cell
autoimmune disease & examples
Allergies
There are instances when the immune response to innocuous substances is inappropriately overwhelming = Allergies
There are instances when the immune response to innocuous substances is inappropriately overwhelming
Allergies
Two Main Fluid Systems of Immune System
The Hematopoietic (blood) and Lymphatic Systems
Cells in the hematopoietic system
Erythrocytes or red blood cells (RBCs)
Leukocytes or white blood cells (WBCs)
Thrombocytes or platelets
What do Erythrocytes function and what system are they apart of?
Erythrocytes or red blood cells (RBCs) - Carry oxygen
Hematopoietic system
What do Leukocytes function and what system are they apart of?
Leukocytes or white blood cells (WBCs) ; Fight infections
Hematopoietic system
What do Leukocytes function and what system are they apart of?
Thrombocytes or platelets - Help control bleeding; clotting
Hematopoietic System
All these cell types in the Hematopoietic system develop from a common cell in the ________ ________ ; The _______ ____________ _______ _______
Bone Marrow ; The pluripotent hematopoietic stem cell
If all the cells in the hematopoietic system all develop from The pluripotent hematopoietic stem cell how do they become different?
They differentiate into these different cell types by interactions with dozens of glycoproteins called hematopoietic growth factors
Leukocytes; Function, types and location
Leukocytes or white blood cells (WBCs), are responsible for protecting the body from infection and part of the immune system
Granulocytes (containing large granules in the cytoplasm)
Agranulocytes (without granules)
What white blood cells contain granules
Granulocytes are WBCs with secretory granules & consist of
Neutrophils
Eosinophils
Basophils
What white blood cell do not contain granules
Agranulocytes are lymphocytes (single large nucleus, no granules)
Consisting of B cells, T cells, and monocytes
Lymphocytes circulate in the blood and lymph systems and make their home in the lymphoid organs
What are Lymphocytes?
Agranulocytes are lymphocytes (single large nucleus, no granules)
Consisting of B cells, T cells, and monocytes
Lymphocytes circulate in the blood and lymph systems and make their home in the lymphoid organs
What are the main cells of the lymphatic system
T and B cells are the main cells of the lymphatic system
______ is clear, transparent, and colorless
Lymph
what is Lymph?
Lymph is clear, transparent, and colorless
It flows in the lymphatic vessels alongside the blood vessels, bathing tissues and organs in its protective covering
Along the lymph vessels, there are lymph nodes that serve as filters of the lymphatic fluid
It is in the lymph nodes where ______ are usually presented to the immune system
Antigens
Along the lymph ________ , there are _____ ______ that serve as _______ of the lymphatic fluid
Along the lymph vessels, there are lymph nodes that serve as filters of the lymphatic fluid
It is in the_______ _______where antigens are usually presented to the immune system
Lymph nodes
What are the Primary Organs of the Immune System
Bone Marrow & Thymus Gland
What produces B Cells
Bone Marrow
What produces T Cells?
Thymus Gland
They are produced in the bone marrow and mature in the thymus
What cells are involved in humoral immunity (related to antibodies)
B Cells
________ ________ produces antigen-specific antibodies and is primarily driven by B cells
Humoral Immunity
Humoral immunity produces antigen-specific antibodies and is primarily driven by _____ cells
B Cells
Cell-mediated immunity does not depend on antibodies for its adaptive immune functions and is primarily driven by mature_____ cells
T Cells
_______ ________ does not depend on antibodies for its adaptive immune functions and is primarily driven by mature T cells
Cell-mediated immunity
T- Cells; Produced & Function
Thymus gland = T cells
They are produced in the bone marrow and mature in the thymus
T cells are involved in cell-mediated immunity
- Cell-mediated immunity does not depend on antibodies for its adaptive immune functions and is primarily driven by mature T cells
The function of T cells and B cells is to recognize specific “non-self” antigens, during a process known as antigen presentation
B- Cells; Produced & Function
Bone marrow = B Cells
B cells are involved in humoral immunity (related to antibodies)
- Humoral immunity produces antigen-specific antibodies and is primarily driven by B cells
The function of T cells and B cells is to recognize specific “non-self” antigens, during a process known as antigen presentation
What is the function of T & B cells?
The function of T cells and B cells is to recognize specific “non-self” antigens, during a process known as antigen presentation
Secondary organs for the immune system
Adenoids, tonsils, spleen, lymph nodes, appendix and Peyer’s patches (within the intestines)
WBCs originate in the bone marrow and then migrate to the other primary and secondary lymph organs
What cells originate in the bone marrow and then migrate to the other primary and secondary lymph organs
White Blood Cells