QUIZ 1 - MSN 6204 Flashcards

1
Q

Synbiotics are a combination of prebiotic and probiotic agents. This
combination is supposed to:

enhance the survival of the probiotic bacteria through the upper GIT

improve implantation of the probiotic strain in the colon

have a stimulating effect on the growth and/or activities of both the exogenously provided probiotic strain(s) and the endogenous inhabitants of the bowel

Do all of the above

Do none of the above

A

Do all of the above Correct!

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2
Q

Which of the following probiotic products has clinical trial evidence of efficacy for the treatment of infantile colic?

Culturelle Kids Probiotic
Natural Factors Children’s Multi Probiotic
Bio-Kult Infantis
Klaire Labs Ther-Biotic Children’s Chewable

A

Bio-Kult Infantis Correct!

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3
Q

Based on the most recent research, probiotics can be used to treat:

Endometriosis
Post-partum obesity
Mastitis
All of the above

A

All of the above

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4
Q

The probiotic strain Lactobacillus reuteri DSM17938 is found in which commercially-available probiotic preparation in the USA?

Bioceuticals UltraBiotic 45
Natren Healthy Trinity
Gerber Soother Colic Drops
Standard Process ProSynbiotic

A

Gerber Soother Colic Drops Correct!

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5
Q

What differentiates prebiotics from colonic foods?

Only colonic foods are fermented to produce short-chain fatty acids

Prebiotics are only utilized by a limited number of beneficial bacteria in the human GIT

Prebiotics have to be naturally-occurring, whereas colonic foods do not

Nothing differentiates them – they are different terms for the same thing

Only prebiotics are fermented to produce short-chain fatty acids

A

Prebiotics are only utilized by a limited number of beneficial bacteria in the human GIT

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6
Q

A probiotic strain that has demonstrated efficacy in the prevention of atopic eczema is:

Lactobacillus rhamnosus VRI-003
Lactobacillus rhamnosus HN001
Bifidobacterium lactis HN01
Lactobacillus acidophilus LAVRI-A1

A

Lactobacillus rhamnosus HN001

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7
Q

Probiotic characteristics are strain dependent. This means:

Desirable characteristics cannot be extrapolated across the species level
Strains within the same species may have differing therapeutic qualities
One cannot generalize research results conducted on one probiotic strain to another one, even if it is within the same species
All of the above

A

All of the above

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8
Q

Which prebiotic has been shown to increase microbial β-glucosidase activity in the colon?

Larch arabinogalactans
Galactooligosaccharides
Fructooligosaccharides
Lactulose
Apple pectin

A

Fructooligosaccharides

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9
Q

A prebiotic must have all the following characteristics except one. The exception is:

ingestion of the substance alters the colonic microflora ecosystem towards a healthier composition

the substance must be neither catabolized nor absorbed in the stomach or small intestine

ingestion results in changes that improve the health of the host

the substance must be naturally occurring

the substance must be a selective substrate only utilized by a limited number of beneficial bacteria

A

the substance must be naturally occurring

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10
Q

All of the following are desirable probiotic characteristics except one; choose the exception:

Human origin
Documented clinical safety
Adherence to the intestinal mucosa
Ability to colonize the human gastrointestinal tract (albeit only temporarily)
Antagonism against lactobacilli and bifidobacteria

A

Antagonism against lactobacilli and bifidobacteria

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11
Q

What is the best rationale to base your prescribing of a particular probiotic supplement on?

Your clinical experience

Your colleagues’ clinical experience

Choose the supplement with the highest CFU (colony forming units)

Clinical trial level evidence of efficacy

Claims made in a manufacturers’ brochure

A

Clinical trial level evidence of efficacy

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12
Q

Which of the following is not a mechanism by which probiotics work:

Conversion of excess intestinal gases to water

Competition for space and nutrients with potential
pathogens

Production of selectively-acting anti-microbial substances Via interaction with immune cells along the GIT

Via production of beneficial compounds in the GIT (e.g., polyamines)

A

Conversion of excess intestinal gases to water

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13
Q

Which of the following is not a common side effect from prebiotic administration?

Flatulence
Abdominal distension
Sore joints
Abdominal bloating
Abdominal pain

A

Sore joints

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14
Q

What is the prebiotic of choice to prevent Traveler’s diarrhea?

Fructooligosaccharides
Galactooligosaccharides
Larch arabinogalactans
Raffinose

A

Galactooligosaccharides

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15
Q

What is the general rule of dosing with prebiotic compounds?

Start low and slowly work your way up to the ideal therapeutic dose

Start with the ideal therapeutic dose and if this causes symptoms, slowly reduce the dose until it appears well-tolerated

They work synergistically, so it is best to give a number of them

concurrently to maximize effectiveness

None of the above

A

Start low and slowly work your way up to the ideal therapeutic dose

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16
Q

What is the minimum therapeutic dose of a probiotic strain?

It differs per strain, but it is prudent to prescribe a minimum of 1 billion (10^9) colony forming units (CFU) of each strain

It differs per strain, but it is prudent to prescribe a minimum of 100 million CFU (10^8) of each strain

10 billion (10^10) CFU

100,000 (10^6) CFU

A

It differs per strain, but it is prudent to prescribe a minimum of 1 billion (10^9) colony forming units (CFU) of each strain

17
Q

Which of the following is not a probiotic myth?

Never take probiotics alongside antibiotics as it is a waste of money

Probiotics are best taken on an empty stomach

Probiotics are best taken with larger, more dense meals to enhance survival through the upper GIT

A good probiotic strain will permanently colonize the human GIT after consumption

Probiotic supplements are superior to probiotic foods as therapeutic tools

A

Probiotics are best taken with larger, more dense meals to enhance survival through the upper GIT

18
Q

Based on clinical trial data, the probiotic strains of choice in bacterial vaginosis are:

Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12

Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14

Lactobacillus plantarum Lp-115 and Lactobacillus rhamnosus CUL-63

Lactobacillus rhamnosus CUL-63 and Lactobacillus fermentum CUL-67

A

Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14

19
Q

All of the following are prebiotics except one. Choose the exception:

fructooligosaccharides

lactulose

larch arabinogalactans

galactooligosaccharides

A

larch arabinogalactans

20
Q

A species commonly used in probiotic supplements is:

Klebsiella pneumoniae
Campylobacter jejuni
Bacillus anthracis
Saccharomyces cerevisiae

A

Saccharomyces cerevisiae