Quinolone Flashcards
1
Q
First gen characteristics
A
- limited activity vs gram posive
- only for UTI
- oxolinic acid
2
Q
Second gen characteristics
A
- fluorine at C6
- piperazine at C7
- cipro is most potent
- broader spectrum of bacterial cidal activity and are more potent
- more gram +
3
Q
third and fourth gen
A
- improved activity against gram +
- levo and moxifloxacin and ozenoxacin
- drug of last resort
- 40-100 fold increase in potency
4
Q
What is ozenoxacin used to treat
A
staphylococcus aueros or streptococcus pyogenes
5
Q
what is delafloxicin used for
A
skin infectiosn and MRSA
6
Q
quinolones MOA
A
DNA religation is blocked at the topo II religation site
7
Q
quinolon resitance
A
- low relative to other antibacterial agents
8
Q
PK
A
orally absorbed
- CSF levels exceed serum concentrations when meninges are inflamed
- chelates with metals
9
Q
metabolism
A
glucuronide
10
Q
gatifloxcin
A
hyperglycemia and hypoglycemai in
