Exam Two Flashcards
Mechanism of action of beta lactam antibiotics
inhibitors of cell wall synthesis
mechanism of resistance of beta lactam antibiotics
- destruction by beta lactamase enzymes
- alteration in PBPs (not aztreonam)
- decrease permeability of the outer cell membrane in gram negative bacteria
what are the pharmacodynamic properties of beta lactams
time dependent bactericidal activity (except against enterococcus)
What is the elimination half life of most beta lactams
< 2 hours
How are most beta lactams eliminated
renally
Which beta lactams are not eliminated renally?
- nafcillin
- oxacillin
- ceftriaxone
- cefoperazone
Are all beta lactams cross allergenic?
all except aztreonam
Natural Penicillins SOA
- Most non beta lactamase producing gram positive cocci and bacilli
- very little staphylococcus
- gram negative cocci
- anaerobes
Penicillinase-Resistant Penicillins (nafcillin, methicillin, oxacillin, dicloxacillin) SOA
MSSA
Aminopenicillins (ampicillin and amoxacillin) SOA
- ineffective against staphylococcus aureus
- better against enterococcus
- excellent against listeria monocytogenes
- Gram Negatives
- anaerobes
What is ampicillin the drug of choice for
listeria monocytogenes and enterococcus
Carboxypenicillins (ticarcillin) SOA
- weak gram positive activity (no activity against staphylococcus)
- gram negative (including pseudomonas)
- not active against klebsiella or serratia
Ureidopenicillins (piperacillin) SOA
- good gram positive
- no activity against staphylococcus
- improved activity of gram negatives (including pseudomonas aeruginosa)
- anaerobes similar to Pen G with some activity against B fragilis
Which penicillin has the most activity against pseudomonas
piperacillin
Beta lactamase inhibitor combination penicilllins SOA
- staphylococcus aureus (MSSA)
- enahnced activity of some gram negative
- Anaerobes (B. fragilis and DOT organisms)
Are penicillins bactericidal or bacteriostatic against enterococcus
bacteriostatic
Does food delay the rate and/extent of absorption of penicillins?
Yes
Penicillin distribution to the CSF
only in the presence of inflamed meninges when high, maximal doses of parenteral penicillins are used
Where are nafcillin and oxacillin eliminated?
liver
Where is piperacillin eliminated
dual elimination
Which agents cause sodium load and must be considered in patients with CHF or renal dysfunction?
- aqueous penicillin G
- nafcillin
- ticarcillin
- piperacillin
- carbenicillin
Natural penicillin use
- streptococcus pneumonia (PSSP or PISP)
- treponema pallidum (syphilis)
Penicillinase Resistant Penicillins (nafcillin, oxacillin)
- MSSA
Aminopenicillin use
Enterococcal infections and listeria monocytogenes