QUANTITATIVE DISORDER Flashcards
FROM external factor that you took in your body that affects plt function
Acquired defect of plt function
Drug related to acquired defects of plt defects
- Aspirin
- Cox-2 inhibitors (naproxen and ibuprofen)
- Ticlopidine and Clopidogrel
- Dextran
Acetylate the cyclooxygenase enzyme
Aspirin and NSAIDs aspirin
Secrets thromboxane
cyclooxygenase
Stimulating the division Of plt, these are from blood vessel wall when they contract
Thromboxane and prostaglandin
Rejection due to prolonged bleeding of px
COX-inhibitor
Anti plt medication
Ticlopidine and clopidogrel
Prevent blood clot inside the BV by preventing plt aggregation
Anti plt medication
Administered to enhance fibrinolysis
dextran
What does dextran do to vWF
Reduce plt adhesion to vWF
Significant plt level
<100,000/ul- abnormally low
30,000-50,000/ul- bleeding possible
<30,000/ul- spontaneous bleeding
<5,000/ul- severe spontaneous bleeding
2 General quantitative disorder
- Thrombocytopenia
- Thrombocytosis
thrombocytopenia
Possible bleeding anytime for the px
Decreased in circulating plt
<100,000/ul
Normal plt ct
150,000-450,000X10/ul
thrombocytosis
Hallmark for myeloproliferative diseases
Inc in circulating plt
>450,000/ul
Associated with specific gene chromosomal abnormality
Inherited/congenital hypoplasia
Large plt, dohle like bodies (20 um)
Mutation in MYH9 gene
May Hegglin anomaly
Encodes for the myosin heavy chain which affects plt activation
MYH9 gene
Absence hypoplasia in radial bones
TAR SYNDROME
Bone and visceral organ abnormalities
Pancytopenia
neonates
FANCONI SYNDROME
Small plts
Absence of megakaryocytes
Chlorthiazide tolbutamide
Neonatal Thrombocytopenia
What is TORCH
Toxoplasma Rubella CMV HIV-herpes
72 hours of birth
Baby is Exposed to TORCH infection
BSS
Low plt
Dense granules
Small plts
WISKOTT ALDRICH
Suppresses BM megakaryocyte production and other cell
Acquired/ Drug induced hypoplasia
For HIV treatment
ZIDOVUDINE
ANAGRELIDE
Treatment for thrombocytosis
Long term consumption to this substance will be subjected to thrombocytopenia
ethanol
Restoring plt due to chemotherapy to stimulate BM to produce more megakaryocyte
IL2
Ineffective thrombopoiesis
Seen in megaloblastic anemia
Impaired DNA synthesis
platelets
Marrow replacement by abnormal cells
In the BM preventing maturation and growth of megakaryocyte
