QUANTITATIVE DISORDER Flashcards

1
Q

FROM external factor that you took in your body that affects plt function

A

Acquired defect of plt function

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2
Q

Drug related to acquired defects of plt defects

A
  1. Aspirin
  2. Cox-2 inhibitors (naproxen and ibuprofen)
  3. Ticlopidine and Clopidogrel
  4. Dextran
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3
Q

Acetylate the cyclooxygenase enzyme

A

Aspirin and NSAIDs aspirin

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4
Q

Secrets thromboxane

A

cyclooxygenase

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5
Q

Stimulating the division Of plt, these are from blood vessel wall when they contract

A

Thromboxane and prostaglandin

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6
Q

Rejection due to prolonged bleeding of px

A

COX-inhibitor

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7
Q

Anti plt medication

A

Ticlopidine and clopidogrel

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8
Q

Prevent blood clot inside the BV by preventing plt aggregation

A

Anti plt medication

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9
Q

Administered to enhance fibrinolysis

A

dextran

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10
Q

What does dextran do to vWF

A

Reduce plt adhesion to vWF

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11
Q

Significant plt level

A

<100,000/ul- abnormally low
30,000-50,000/ul- bleeding possible
<30,000/ul- spontaneous bleeding
<5,000/ul- severe spontaneous bleeding

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12
Q

2 General quantitative disorder

A
  1. Thrombocytopenia
  2. Thrombocytosis
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13
Q

thrombocytopenia

A

Possible bleeding anytime for the px
Decreased in circulating plt
<100,000/ul

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14
Q

Normal plt ct

A

150,000-450,000X10/ul

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15
Q

thrombocytosis

A

Hallmark for myeloproliferative diseases
Inc in circulating plt
>450,000/ul

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16
Q

Associated with specific gene chromosomal abnormality

A

Inherited/congenital hypoplasia

17
Q

Large plt, dohle like bodies (20 um)
Mutation in MYH9 gene

A

May Hegglin anomaly

18
Q

Encodes for the myosin heavy chain which affects plt activation

19
Q

Absence hypoplasia in radial bones

A

TAR SYNDROME

20
Q

Bone and visceral organ abnormalities
Pancytopenia
neonates

A

FANCONI SYNDROME

21
Q

Small plts
Absence of megakaryocytes
Chlorthiazide tolbutamide

A

Neonatal Thrombocytopenia

22
Q

What is TORCH

A

Toxoplasma Rubella CMV HIV-herpes

23
Q

72 hours of birth

A

Baby is Exposed to TORCH infection

24
Q

BSS

25
Dense granules Small plts
WISKOTT ALDRICH
26
Suppresses BM megakaryocyte production and other cell
Acquired/ Drug induced hypoplasia
27
For HIV treatment
ZIDOVUDINE
28
ANAGRELIDE
Treatment for thrombocytosis
29
Long term consumption to this substance will be subjected to thrombocytopenia
ethanol
30
Restoring plt due to chemotherapy to stimulate BM to produce more megakaryocyte
IL2
31
Ineffective thrombopoiesis
Seen in megaloblastic anemia Impaired DNA synthesis platelets
32
Marrow replacement by abnormal cells
In the BM preventing maturation and growth of megakaryocyte