QUANTITATIVE DISORDER

Question 1

FROM external factor that you took in your body that affects plt function

Answer 1

Acquired defect of plt function

Question 2

Drug related to acquired defects of plt defects

Answer 2

1. Aspirin
2. Cox-2 inhibitors (naproxen and ibuprofen)
3. Ticlopidine and Clopidogrel
4. Dextran

Question 3

Acetylate the cyclooxygenase enzyme

Answer 3

Aspirin and NSAIDs aspirin

Question 4

Secrets thromboxane

Answer 4

cyclooxygenase

Question 5

Stimulating the division Of plt, these are from blood vessel wall when they contract

Answer 5

Thromboxane and prostaglandin

Question 6

Rejection due to prolonged bleeding of px

Answer 6

COX-inhibitor

Question 7

Anti plt medication

Answer 7

Ticlopidine and clopidogrel

Question 8

Prevent blood clot inside the BV by preventing plt aggregation

Answer 8

Anti plt medication

Question 9

Administered to enhance fibrinolysis

Answer 9

dextran

Question 10

What does dextran do to vWF

Answer 10

Reduce plt adhesion to vWF

Question 11

Significant plt level

Answer 11

<100,000/ul- abnormally low
30,000-50,000/ul- bleeding possible
<30,000/ul- spontaneous bleeding
<5,000/ul- severe spontaneous bleeding

Question 12

2 General quantitative disorder

Answer 12

1. Thrombocytopenia
2. Thrombocytosis

Question 13

thrombocytopenia

Answer 13

Possible bleeding anytime for the px
Decreased in circulating plt
<100,000/ul

Question 14

Normal plt ct

Answer 14

150,000-450,000X10/ul

Question 15

thrombocytosis

Answer 15

Hallmark for myeloproliferative diseases
Inc in circulating plt
>450,000/ul

Question 16

Associated with specific gene chromosomal abnormality

Answer 16

Inherited/congenital hypoplasia

Question 17

Large plt, dohle like bodies (20 um)
Mutation in MYH9 gene

Answer 17

May Hegglin anomaly

Question 18

Encodes for the myosin heavy chain which affects plt activation

Answer 18

MYH9 gene

Question 19

Absence hypoplasia in radial bones

Answer 19

TAR SYNDROME

Question 20

Bone and visceral organ abnormalities
Pancytopenia
neonates

Answer 20

FANCONI SYNDROME

Question 21

Small plts
Absence of megakaryocytes
Chlorthiazide tolbutamide

Answer 21

Neonatal Thrombocytopenia

Question 22

What is TORCH

Answer 22

Toxoplasma Rubella CMV HIV-herpes

Question 23

72 hours of birth

Answer 23

Baby is Exposed to TORCH infection

Question 24

BSS

Answer 24

Low plt

Question 25

Dense granules
Small plts

Answer 25

WISKOTT ALDRICH

Question 26

Suppresses BM megakaryocyte production and other cell

Answer 26

Acquired/ Drug induced hypoplasia

Question 27

For HIV treatment

Answer 27

ZIDOVUDINE

Question 28

ANAGRELIDE

Answer 28

Treatment for thrombocytosis

Question 29

Long term consumption to this substance will be subjected to thrombocytopenia

Answer 29

ethanol

Question 30

Restoring plt due to chemotherapy to stimulate BM to produce more megakaryocyte

Answer 30

IL2

Question 31

Ineffective thrombopoiesis

Answer 31

Seen in megaloblastic anemia
Impaired DNA synthesis
platelets

Question 32

Marrow replacement by abnormal cells

Answer 32

In the BM preventing maturation and growth of megakaryocyte