CASCADE Flashcards
WHAT IS THE COFACTOR OF XII IN ACTIVATING PLASMINOGEN
KALLIKREIN
Activates HMWK to produce KININ
KALLIKREIN
What factor stabilizes or crosslinks fibrin/fibrinopeptide
Factor XIII
What activates factor XI ( thromboplastin antecedent )
Factor XIIa
Activated by factor XIIa
Factor XI (thromboplastin)
Prekallikrein to kallikrein
Factor XI to XIa
Composition of Intrinsic tenase which activates Factor X
Factor IXa
Calcium
Phospholipids
VIIIa
This activates fibrinolysis and complement system
Plasmin
Composition of Prothrombinase
Factor Xa
Va
Calcium
Phospholipid
What activates XII to XIIa
Exposed collagen
Platelet
Negative surface
Known as feedback mechanism
HMWK+Kallikrein (enzymatically cleave)
Cleave factor XIIa to fragmented XII
plasmin
Produces kinin system
KININ
What is known as glass factor or contact factor
Glass factor or contact factor
For chemotaxis and Inflammation
KININ SYSTEM
Intrinsic pathway is initiated by the activation of what factor
Factor XII (zymogen) to XIIa (activated protease)
Activates IX to IXa
Factor XIa
Composition of extrinsic tenase which activates factor X
VIIa
Calcium
Tissue factor (factor III)
Wht is the other name of factor X
Stuart Prower Factor
Marks the end of contact activation phase
Activation of IX to IXa
Initiated upon the release of tissue factor (Factor III)
Extrinsic pathway
Occurs in vivo
Extrinsic pathway
Occurs in vivo
Extrinsic pathway
What factor activate factor VII to VIIa
Factor III or Tissue factor
What is called the cleavage of FX to Xa
TENASE
Factor Xa activates Prothrombin (FII) to Thrombin (FIIa) with the help of what cofactor
Cofactor V
Thrombin also activates other factor such as
FIX as well as cofactor VIIIa and FXIII (stabilizing factor)
What is the final step of the coagulation cascade
FIBRINOGEN
