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HEMATOLOGY 2 > CASCADE > Flashcards

CASCADE Flashcards

1
Q

WHAT IS THE COFACTOR OF XII IN ACTIVATING PLASMINOGEN

A

KALLIKREIN

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2
Q

Activates HMWK to produce KININ

A

KALLIKREIN

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3
Q

What factor stabilizes or crosslinks fibrin/fibrinopeptide

A

Factor XIII

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4
Q

What activates factor XI ( thromboplastin antecedent )

A

Factor XIIa

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5
Q

Activated by factor XIIa

A

Factor XI (thromboplastin)
Prekallikrein to kallikrein
Factor XI to XIa

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6
Q

Composition of Intrinsic tenase which activates Factor X

A

Factor IXa
Calcium
Phospholipids
VIIIa

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7
Q

This activates fibrinolysis and complement system

A

Plasmin

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8
Q

Composition of Prothrombinase

A

Factor Xa
Va
Calcium
Phospholipid

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9
Q

What activates XII to XIIa

A

Exposed collagen
Platelet
Negative surface

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10
Q

Known as feedback mechanism

A

HMWK+Kallikrein (enzymatically cleave)

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11
Q

Cleave factor XIIa to fragmented XII

A

plasmin

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12
Q

Produces kinin system

A

KININ

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13
Q

What is known as glass factor or contact factor

A

Glass factor or contact factor

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14
Q

For chemotaxis and Inflammation

A

KININ SYSTEM

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15
Q

Intrinsic pathway is initiated by the activation of what factor

A

Factor XII (zymogen) to XIIa (activated protease)

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16
Q

Activates IX to IXa

A

Factor XIa

17
Q

Composition of extrinsic tenase which activates factor X

A

VIIa
Calcium
Tissue factor (factor III)

18
Q

Wht is the other name of factor X

A

Stuart Prower Factor

19
Q

Marks the end of contact activation phase

A

Activation of IX to IXa

20
Q

Initiated upon the release of tissue factor (Factor III)

A

Extrinsic pathway

21
Q

Occurs in vivo

A

Extrinsic pathway

22
Q

Occurs in vivo

A

Extrinsic pathway

23
Q

What factor activate factor VII to VIIa

A

Factor III or Tissue factor

24
Q

What is called the cleavage of FX to Xa

A

TENASE

25
Q

Factor Xa activates Prothrombin (FII) to Thrombin (FIIa) with the help of what cofactor

A

Cofactor V

26
Q

Thrombin also activates other factor such as

A

FIX as well as cofactor VIIIa and FXIII (stabilizing factor)

27
Q

What is the final step of the coagulation cascade

A

FIBRINOGEN

HEMATOLOGY 2 (5 decks)

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