PLATELETS Flashcards
WHAT RESEMBLES MYELOBLAST AND PRONORMOBLAST
MEGAKARYOBLAST
CYTOPLASM IS ABUNDANT, WITH MINIMAL LOBULARITY
PROMEGAKARYOCYTE
WHERE DOES MEGAKARYOBLAST ARISE
MEGAKARYOPOIESIS
WHAT IS THE DEMARCATION MARK OF MEGAKAYOCYTE
CYTOPLASMIC EXTENSION
NUCLEUS IS LOBULATED AND BASOPHILIC
MEGAKARYOCYTE
CYTOPLASM IS GRANULAR AND AZUROPHILIC WITH DMS
MEGAKARYOCYTE
WHAT STAGE IN MEGAKARYOCYTE STAGE IS THE FUTURE PLATELET
METAMEGAKARYOCYTE
DO ALL METAMEGAKARYOCYTE PRODUCE PLATELET?
NO
MK-1 NUCLEUS
ROUND
MK-III NUCLEUS
MULTILOBED
MK-II NUCLEUS
INDENTED
CHROMATIN APPEARANCE OF MK-II
MODERATELY CONDENSED
CHROMATIN OF MK-I
HOMOGENEOUS
CHROMAIN OF MK-III
DEEPLY AND VARIABLY CONDENSED
PRESENCE OF ENDOMITOSIS IN MK-1
PRESENT
PRESENCE OF ENDOMITOSIS IN MK-II
ENDS
PRESENCE OF ENDOMITOSIS IN MK-III
ABSENT
WHERE DOES PLT ORIGINATES
MEGAKARYOCYTE CYTOPLASM
AVERAGE SIZE OF PLATELET
2-4 um
size of platelet in range
2.5 um
what hormone induces platelet shedding
IL3, VI, XI
WHAT IS THE LIFESPAN OF PLATELET
9-10 DAYS
who has higher plt count male or female
female
Platelet mpv
7 fL
Normal count of platelet
150-450X10^9/L
Plt in men
122-350
Plt in women
140-379
2 types of plt
Resting plt
Stress plt
Also known as circulating plt
Resting plt
Also Known as reticulated plt
Stress plt
Appearance of resting plt
Normally biconvex
Appearance of markedly larger than normal plt
Stress plt
Shape of resting and stress plt in EDTA
round
Appearance of stress plt in citrated blood
Cylindrical/beaded
MPV of stress plt
12-14 fL
What type of platelet flow smoothly in veins
Resting plt
What does stress plt carries
Ribosomes and fragment of RER
Moves back and forth from the venules to the white pulp
Resting plt
Comes from rapid extension and release
Stress plt
Which of the 2 type of plt is prothrombic
Stress plt
Which of the 2 types of plt is sequestered plt
Resting plt
What factor Is phospholipid membrane seen
Plt factor III
Functions of plt
Primary hemostasis
Secondary hemostasis
PF 3
Lipoprotein found in plt granules and membranes and required in 2 steps of the coagulation factor
PF 4
Glycoprotein stored in alpha granules , aids in ADP induced plt aggregation and inhibits effects of heparin
What maintain vascular integrity
Primary hemostasis
Participates in blood coagulation
Secondary hemostasis
What does peripheral zone contain
Glycocalyx, plasma membrane, submembrane area
Thick than RBCS dense than any blood cells
glycocalyx
What support discoid shape of plt
Microtubules
microfilaments
What are the surface adherence of the factor VIII
I,V,VII,XI,XII,XIII
UNDERLIES THE PLASMA MEMBRANE , RECEIVES MESSAGE FROM THE OUTSIDE
Sumbmembrane area
Contractile force after activation of plasma
tubulin
Cytoskeleton contains
Actin and myosin
thrombosthenin
Equivalent of actin and myosin in plts
UNDERLIES the submembrane filaments
Sol-gel zone
Communication of the organelles
Sol gel stable gel
IIB-IIIA
For aggregation
2 types of membrane system
- Open canalicular system
- Dense tubular system
For external communication
Open canalicular system
For arachidonic synthesis
Dense tubular system
What is the dense granule of HMWK
ADP
What is the dense granule of FIBRINOGEN
ATP
What is the dense granule of factor V,VIII
calcium
What is the dense granule of thrombospondin
magnesium
What is the dense granule of PF4
serotonin
Adheres to detach/injured endothelium
Adhesion
Platelet release rxn
Shape change
Alpha and dense granules release substance
vasoconstriction
serotonin
Platelet aggregation
Glycoprotein and fibrinogen
Clot formation
PF3
site of arachidonic acid synthesis
DENSE TUBULAR SYSTEM
direct communication with extracellular environment
OPEN CANALICULAR SYSTEM