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HEMATOLOGY 2 > PLATELETS > Flashcards

PLATELETS Flashcards

1
Q

WHAT RESEMBLES MYELOBLAST AND PRONORMOBLAST

A

MEGAKARYOBLAST

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2
Q

CYTOPLASM IS ABUNDANT, WITH MINIMAL LOBULARITY

A

PROMEGAKARYOCYTE

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3
Q

WHERE DOES MEGAKARYOBLAST ARISE

A

MEGAKARYOPOIESIS

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4
Q

WHAT IS THE DEMARCATION MARK OF MEGAKAYOCYTE

A

CYTOPLASMIC EXTENSION

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5
Q

NUCLEUS IS LOBULATED AND BASOPHILIC

A

MEGAKARYOCYTE

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6
Q

CYTOPLASM IS GRANULAR AND AZUROPHILIC WITH DMS

A

MEGAKARYOCYTE

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7
Q

WHAT STAGE IN MEGAKARYOCYTE STAGE IS THE FUTURE PLATELET

A

METAMEGAKARYOCYTE

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8
Q

DO ALL METAMEGAKARYOCYTE PRODUCE PLATELET?

A

NO

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9
Q

MK-1 NUCLEUS

A

ROUND

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10
Q

MK-III NUCLEUS

A

MULTILOBED

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11
Q

MK-II NUCLEUS

A

INDENTED

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12
Q

CHROMATIN APPEARANCE OF MK-II

A

MODERATELY CONDENSED

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13
Q

CHROMATIN OF MK-I

A

HOMOGENEOUS

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14
Q

CHROMAIN OF MK-III

A

DEEPLY AND VARIABLY CONDENSED

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15
Q

PRESENCE OF ENDOMITOSIS IN MK-1

A

PRESENT

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16
Q

PRESENCE OF ENDOMITOSIS IN MK-II

A

ENDS

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17
Q

PRESENCE OF ENDOMITOSIS IN MK-III

A

ABSENT

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18
Q

WHERE DOES PLT ORIGINATES

A

MEGAKARYOCYTE CYTOPLASM

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19
Q

AVERAGE SIZE OF PLATELET

A

2-4 um

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20
Q

size of platelet in range

A

2.5 um

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21
Q

what hormone induces platelet shedding

A

IL3, VI, XI

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22
Q

WHAT IS THE LIFESPAN OF PLATELET

A

9-10 DAYS

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23
Q

who has higher plt count male or female

A

female

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24
Q

Platelet mpv

A

7 fL

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25
Q

Normal count of platelet

A

150-450X10^9/L

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26
Q

Plt in men

A

122-350

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27
Q

Plt in women

A

140-379

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28
Q

2 types of plt

A

Resting plt
Stress plt

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29
Q

Also known as circulating plt

A

Resting plt

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30
Q

Also Known as reticulated plt

A

Stress plt

31
Q

Appearance of resting plt

A

Normally biconvex

32
Q

Appearance of markedly larger than normal plt

A

Stress plt

33
Q

Shape of resting and stress plt in EDTA

A

round

34
Q

Appearance of stress plt in citrated blood

A

Cylindrical/beaded

35
Q

MPV of stress plt

A

12-14 fL

36
Q

What type of platelet flow smoothly in veins

A

Resting plt

37
Q

What does stress plt carries

A

Ribosomes and fragment of RER

38
Q

Moves back and forth from the venules to the white pulp

A

Resting plt

39
Q

Comes from rapid extension and release

A

Stress plt

40
Q

Which of the 2 type of plt is prothrombic

A

Stress plt

41
Q

Which of the 2 types of plt is sequestered plt

A

Resting plt

42
Q

What factor Is phospholipid membrane seen

A

Plt factor III

43
Q

Functions of plt

A

Primary hemostasis
Secondary hemostasis

44
Q

PF 3

A

Lipoprotein found in plt granules and membranes and required in 2 steps of the coagulation factor

45
Q

PF 4

A

Glycoprotein stored in alpha granules , aids in ADP induced plt aggregation and inhibits effects of heparin

46
Q

What maintain vascular integrity

A

Primary hemostasis

47
Q

Participates in blood coagulation

A

Secondary hemostasis

48
Q

What does peripheral zone contain

A

Glycocalyx, plasma membrane, submembrane area

49
Q

Thick than RBCS dense than any blood cells

A

glycocalyx

50
Q

What support discoid shape of plt

A

Microtubules
microfilaments

51
Q

What are the surface adherence of the factor VIII

A

I,V,VII,XI,XII,XIII

52
Q

UNDERLIES THE PLASMA MEMBRANE , RECEIVES MESSAGE FROM THE OUTSIDE

A

Sumbmembrane area

53
Q

Contractile force after activation of plasma

A

tubulin

54
Q

Cytoskeleton contains

A

Actin and myosin

55
Q

thrombosthenin

A

Equivalent of actin and myosin in plts

56
Q

UNDERLIES the submembrane filaments

A

Sol-gel zone

57
Q

Communication of the organelles

A

Sol gel stable gel

58
Q

IIB-IIIA

A

For aggregation

59
Q

2 types of membrane system

A
  1. Open canalicular system
  2. Dense tubular system
60
Q

For external communication

A

Open canalicular system

61
Q

For arachidonic synthesis

A

Dense tubular system

62
Q

What is the dense granule of HMWK

A

ADP

63
Q

What is the dense granule of FIBRINOGEN

A

ATP

64
Q

What is the dense granule of factor V,VIII

A

calcium

65
Q

What is the dense granule of thrombospondin

A

magnesium

66
Q

What is the dense granule of PF4

A

serotonin

67
Q

Adheres to detach/injured endothelium

A

Adhesion

68
Q

Platelet release rxn

A

Shape change
Alpha and dense granules release substance

69
Q

vasoconstriction

A

serotonin

70
Q

Platelet aggregation

A

Glycoprotein and fibrinogen

71
Q

Clot formation

A

PF3

72
Q

site of arachidonic acid synthesis

A

DENSE TUBULAR SYSTEM

73
Q

direct communication with extracellular environment

A

OPEN CANALICULAR SYSTEM

HEMATOLOGY 2 (5 decks)

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