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HEMATOLOGY 2 > PLATELETS > Flashcards

PLATELETS Flashcards

1
Q

WHAT RESEMBLES MYELOBLAST AND PRONORMOBLAST

A

MEGAKARYOBLAST

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2
Q

CYTOPLASM IS ABUNDANT, WITH MINIMAL LOBULARITY

A

PROMEGAKARYOCYTE

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3
Q

WHERE DOES MEGAKARYOBLAST ARISE

A

MEGAKARYOPOIESIS

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4
Q

WHAT IS THE DEMARCATION MARK OF MEGAKAYOCYTE

A

CYTOPLASMIC EXTENSION

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5
Q

NUCLEUS IS LOBULATED AND BASOPHILIC

A

MEGAKARYOCYTE

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6
Q

CYTOPLASM IS GRANULAR AND AZUROPHILIC WITH DMS

A

MEGAKARYOCYTE

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7
Q

WHAT STAGE IN MEGAKARYOCYTE STAGE IS THE FUTURE PLATELET

A

METAMEGAKARYOCYTE

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8
Q

DO ALL METAMEGAKARYOCYTE PRODUCE PLATELET?

A

NO

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9
Q

MK-1 NUCLEUS

A

ROUND

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10
Q

MK-III NUCLEUS

A

MULTILOBED

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11
Q

MK-II NUCLEUS

A

INDENTED

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12
Q

CHROMATIN APPEARANCE OF MK-II

A

MODERATELY CONDENSED

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13
Q

CHROMATIN OF MK-I

A

HOMOGENEOUS

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14
Q

CHROMAIN OF MK-III

A

DEEPLY AND VARIABLY CONDENSED

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15
Q

PRESENCE OF ENDOMITOSIS IN MK-1

A

PRESENT

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16
Q

PRESENCE OF ENDOMITOSIS IN MK-II

A

ENDS

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17
Q

PRESENCE OF ENDOMITOSIS IN MK-III

A

ABSENT

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18
Q

WHERE DOES PLT ORIGINATES

A

MEGAKARYOCYTE CYTOPLASM

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19
Q

AVERAGE SIZE OF PLATELET

A

2-4 um

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20
Q

size of platelet in range

A

2.5 um

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21
Q

what hormone induces platelet shedding

A

IL3, VI, XI

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22
Q

WHAT IS THE LIFESPAN OF PLATELET

A

9-10 DAYS

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23
Q

who has higher plt count male or female

A

female

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24
Q

Platelet mpv

A

7 fL

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25
Normal count of platelet
150-450X10^9/L
26
Plt in men
122-350
27
Plt in women
140-379
28
2 types of plt
Resting plt Stress plt
29
Also known as circulating plt
Resting plt
30
Also Known as reticulated plt
Stress plt
31
Appearance of resting plt
Normally biconvex
32
Appearance of markedly larger than normal plt
Stress plt
33
Shape of resting and stress plt in EDTA
round
34
Appearance of stress plt in citrated blood
Cylindrical/beaded
35
MPV of stress plt
12-14 fL
36
What type of platelet flow smoothly in veins
Resting plt
37
What does stress plt carries
Ribosomes and fragment of RER
38
Moves back and forth from the venules to the white pulp
Resting plt
39
Comes from rapid extension and release
Stress plt
40
Which of the 2 type of plt is prothrombic
Stress plt
41
Which of the 2 types of plt is sequestered plt
Resting plt
42
What factor Is phospholipid membrane seen
Plt factor III
43
Functions of plt
Primary hemostasis Secondary hemostasis
44
PF 3
Lipoprotein found in plt granules and membranes and required in 2 steps of the coagulation factor
45
PF 4
Glycoprotein stored in alpha granules , aids in ADP induced plt aggregation and inhibits effects of heparin
46
What maintain vascular integrity
Primary hemostasis
47
Participates in blood coagulation
Secondary hemostasis
48
What does peripheral zone contain
Glycocalyx, plasma membrane, submembrane area
49
Thick than RBCS dense than any blood cells
glycocalyx
50
What support discoid shape of plt
Microtubules microfilaments
51
What are the surface adherence of the factor VIII
I,V,VII,XI,XII,XIII
52
UNDERLIES THE PLASMA MEMBRANE , RECEIVES MESSAGE FROM THE OUTSIDE
Sumbmembrane area
53
Contractile force after activation of plasma
tubulin
54
Cytoskeleton contains
Actin and myosin
55
thrombosthenin
Equivalent of actin and myosin in plts
56
UNDERLIES the submembrane filaments
Sol-gel zone
57
Communication of the organelles
Sol gel stable gel
58
IIB-IIIA
For aggregation
59
2 types of membrane system
1. Open canalicular system 2. Dense tubular system
60
For external communication
Open canalicular system
61
For arachidonic synthesis
Dense tubular system
62
What is the dense granule of HMWK
ADP
63
What is the dense granule of FIBRINOGEN
ATP
64
What is the dense granule of factor V,VIII
calcium
65
What is the dense granule of thrombospondin
magnesium
66
What is the dense granule of PF4
serotonin
67
Adheres to detach/injured endothelium
Adhesion
68
Platelet release rxn
Shape change Alpha and dense granules release substance
69
vasoconstriction
serotonin
70
Platelet aggregation
Glycoprotein and fibrinogen
71
Clot formation
PF3
72
site of arachidonic acid synthesis
DENSE TUBULAR SYSTEM
73
direct communication with extracellular environment
OPEN CANALICULAR SYSTEM

HEMATOLOGY 2 (5 decks)

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