MDS MPD Flashcards

1
Q

abnormal development of cell on bm

A

dysplasia

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2
Q

cytopenia of one or more cell line

A

myelodysplastic syndrome

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3
Q

cytosis of all cell line

A

myeloproliferative syndrome

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4
Q

the proliferation outpaces apoptosis

A

myeloproliferatve disorder

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5
Q

results from clonal abnormalities of hematopoietic pluripotent stem cell

A

myelodysplastic syndrome

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6
Q

known to be pre leukemias

A

myelodysplastic syndrome

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7
Q

target age of myelodysplastic syndrome

A

50-70

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8
Q

peripheral blood of mds

A

cytopenia

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9
Q

myeloid cell line of MDS

A

dysplastic

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10
Q

MDS- ACUTE LEUKEMIA

A

1 YEAR

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11
Q

ACUTE LEUKEMIA TO STAGE 1

A

MONTHS

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12
Q

ABNORMAL RBC PRODUCTION LEADING TO MDS

A

DYSERYTHROPOIESIS

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13
Q

ABNORMAL PRODUCTION OF WBSC

A

DYSMYELOPOIESIS

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14
Q

PERSISTENCE OF BASOPHILIA IN THE CYTOPLASM

A

DYSMYELOPOIESIS

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15
Q

PRESENCE OF MICRO AND MACRO CELLS

A

DIMORPHIC RBC POPULATION

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16
Q

MORPHOLOGY OF RBC HAVING VIT 12 DEF AND FOLATE DEFICIENCY

A

OVAL MARCROCYTE

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17
Q

MORPHOLOGIC FEATURE IF HB NOT COMPLETED

A

HYPOCHROMIC MICROCYTE

18
Q

ABNORMAL PRODUCTION OF MEGAKARYOCYTE

A

DYSMEGAKARYPOIESIS

19
Q

SHEDS OF TO BECOME PLT

A

MEGAKARYOCYTE

20
Q

2 TYPES OF MDS

A

PRIMARY MDS
THERAPY RELATED MDS

21
Q

PRIMARY MDS

A
  1. ENVIRONMENTAL EXPOSURE
  2. MUTATION CAUSED BY CHEMICAL, RADIATION , VIRAL INFECTION OR SMOKING
  3. GENETIC INHERITANCE OF HEMATOLOGIC DISORDER
22
Q

CLASSIFICATION OF MDS RELIES ON MORPHOLOGY

A

FAB

23
Q

FAB CLASSIFICATION

A

RELIES ON MORPHOLOGY
DOES NOT ADDRESS THERAPY RELATED OR HEREDITARY FORMS
DOES NOT CONSIDER CHILDHOOD MDS

24
Q

WHO CLASSIFICATION

A

RETAINS FAB FEATURES
RECOGNIZE MOLECULAR, CYTOGENETIC AND IMMUNOLOGIC CHARACTERISTIC
REMOVE CATEGORIES OF CMML AND RAEB-T

25
Q

3 TYPES REFRACTORY CYTOPENIA WITH UNILINEAGE DYSPLSIA

A
  1. REFRACTORY ANEMIA
  2. REFRACTORY NEUTROPENIA
  3. REFRACTORY THROMBOCYTOPENIA
26
Q

RCUD
PROGNOSIS
PROGRESSION

A

5 YEARS PROGNOSIS
6 % PROGRESSION

27
Q

MDS-RS-SLD
PROGNOSIS
PROGRESSION

A

5 YEARS
2 %

28
Q

MDS-RS-MLD
PROGNOSIS
PROGRESSION

A

33 MONTHS
11 %

29
Q

MDS EB2
PROGNOSIS
PROGRESSION

A

<2 YEARS
33 %

30
Q

MDS EB1
PROGNOSIS
PROGRESSION

A

< 2 YEARS
25 %

31
Q

MDS ASSOCIATED WITH DEL (5Q)

A

9 MONTHS
RARE OR NO

32
Q

GENE THAT CONTRIBUTE TO THE SEVERITY OF MDS-RS-SLD

A

SF3B1

33
Q

HOW MANY % ARE THERE IN CASES OF RARS?

A

80 %

34
Q

+ AUER RODS

A

MDS EB2

35
Q

WHAT CHROMOSOME IS MISSING IN MDS ASSOCIATED W ISOLATED DEL 5Q

A

CHROMOSOME 5

36
Q

OCCURS MOST ON OLDER WOMEN

A

MDS ASSOCIATED WITH ASSOCIATED WITH DEL 5Q

37
Q

LACKS SPECIFIC NECESSARY CLASSIFICATIONS

A

MYELODYSPLASTIC SYNDROME

38
Q

KNOWN A DENOVO MDS

A

CHILDHOOD MDS

39
Q

RAEBIT

A

REFRACTORY ANEMIA WITH EXCESS BLAST IN TRANSFORMATION

40
Q

PERIPHERAL BLOOD PERCENTAGE IN FAB CASSIFICATION

A

5 %

41
Q

BM PERCENTAGE IN FAB CASSIFICATION

A

20-30 %

42
Q

AUER ROD +

A

FAB CLASSIFICATION