MDS MPD Flashcards
abnormal development of cell on bm
dysplasia
cytopenia of one or more cell line
myelodysplastic syndrome
cytosis of all cell line
myeloproliferative syndrome
the proliferation outpaces apoptosis
myeloproliferatve disorder
results from clonal abnormalities of hematopoietic pluripotent stem cell
myelodysplastic syndrome
known to be pre leukemias
myelodysplastic syndrome
target age of myelodysplastic syndrome
50-70
peripheral blood of mds
cytopenia
myeloid cell line of MDS
dysplastic
MDS- ACUTE LEUKEMIA
1 YEAR
ACUTE LEUKEMIA TO STAGE 1
MONTHS
ABNORMAL RBC PRODUCTION LEADING TO MDS
DYSERYTHROPOIESIS
ABNORMAL PRODUCTION OF WBSC
DYSMYELOPOIESIS
PERSISTENCE OF BASOPHILIA IN THE CYTOPLASM
DYSMYELOPOIESIS
PRESENCE OF MICRO AND MACRO CELLS
DIMORPHIC RBC POPULATION
MORPHOLOGY OF RBC HAVING VIT 12 DEF AND FOLATE DEFICIENCY
OVAL MARCROCYTE
MORPHOLOGIC FEATURE IF HB NOT COMPLETED
HYPOCHROMIC MICROCYTE
ABNORMAL PRODUCTION OF MEGAKARYOCYTE
DYSMEGAKARYPOIESIS
SHEDS OF TO BECOME PLT
MEGAKARYOCYTE
2 TYPES OF MDS
PRIMARY MDS
THERAPY RELATED MDS
PRIMARY MDS
- ENVIRONMENTAL EXPOSURE
- MUTATION CAUSED BY CHEMICAL, RADIATION , VIRAL INFECTION OR SMOKING
- GENETIC INHERITANCE OF HEMATOLOGIC DISORDER
CLASSIFICATION OF MDS RELIES ON MORPHOLOGY
FAB
FAB CLASSIFICATION
RELIES ON MORPHOLOGY
DOES NOT ADDRESS THERAPY RELATED OR HEREDITARY FORMS
DOES NOT CONSIDER CHILDHOOD MDS
WHO CLASSIFICATION
RETAINS FAB FEATURES
RECOGNIZE MOLECULAR, CYTOGENETIC AND IMMUNOLOGIC CHARACTERISTIC
REMOVE CATEGORIES OF CMML AND RAEB-T
3 TYPES REFRACTORY CYTOPENIA WITH UNILINEAGE DYSPLSIA
- REFRACTORY ANEMIA
- REFRACTORY NEUTROPENIA
- REFRACTORY THROMBOCYTOPENIA
RCUD
PROGNOSIS
PROGRESSION
5 YEARS PROGNOSIS
6 % PROGRESSION
MDS-RS-SLD
PROGNOSIS
PROGRESSION
5 YEARS
2 %
MDS-RS-MLD
PROGNOSIS
PROGRESSION
33 MONTHS
11 %
MDS EB2
PROGNOSIS
PROGRESSION
<2 YEARS
33 %
MDS EB1
PROGNOSIS
PROGRESSION
< 2 YEARS
25 %
MDS ASSOCIATED WITH DEL (5Q)
9 MONTHS
RARE OR NO
GENE THAT CONTRIBUTE TO THE SEVERITY OF MDS-RS-SLD
SF3B1
HOW MANY % ARE THERE IN CASES OF RARS?
80 %
+ AUER RODS
MDS EB2
WHAT CHROMOSOME IS MISSING IN MDS ASSOCIATED W ISOLATED DEL 5Q
CHROMOSOME 5
OCCURS MOST ON OLDER WOMEN
MDS ASSOCIATED WITH ASSOCIATED WITH DEL 5Q
LACKS SPECIFIC NECESSARY CLASSIFICATIONS
MYELODYSPLASTIC SYNDROME
KNOWN A DENOVO MDS
CHILDHOOD MDS
RAEBIT
REFRACTORY ANEMIA WITH EXCESS BLAST IN TRANSFORMATION
PERIPHERAL BLOOD PERCENTAGE IN FAB CASSIFICATION
5 %
BM PERCENTAGE IN FAB CASSIFICATION
20-30 %
AUER ROD +
FAB CLASSIFICATION