MDS MPD Flashcards

1
Q

abnormal development of cell on bm

A

dysplasia

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2
Q

cytopenia of one or more cell line

A

myelodysplastic syndrome

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3
Q

cytosis of all cell line

A

myeloproliferative syndrome

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4
Q

the proliferation outpaces apoptosis

A

myeloproliferatve disorder

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5
Q

results from clonal abnormalities of hematopoietic pluripotent stem cell

A

myelodysplastic syndrome

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6
Q

known to be pre leukemias

A

myelodysplastic syndrome

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7
Q

target age of myelodysplastic syndrome

A

50-70

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8
Q

peripheral blood of mds

A

cytopenia

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9
Q

myeloid cell line of MDS

A

dysplastic

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10
Q

MDS- ACUTE LEUKEMIA

A

1 YEAR

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11
Q

ACUTE LEUKEMIA TO STAGE 1

A

MONTHS

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12
Q

ABNORMAL RBC PRODUCTION LEADING TO MDS

A

DYSERYTHROPOIESIS

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13
Q

ABNORMAL PRODUCTION OF WBSC

A

DYSMYELOPOIESIS

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14
Q

PERSISTENCE OF BASOPHILIA IN THE CYTOPLASM

A

DYSMYELOPOIESIS

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15
Q

PRESENCE OF MICRO AND MACRO CELLS

A

DIMORPHIC RBC POPULATION

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16
Q

MORPHOLOGY OF RBC HAVING VIT 12 DEF AND FOLATE DEFICIENCY

A

OVAL MARCROCYTE

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17
Q

MORPHOLOGIC FEATURE IF HB NOT COMPLETED

A

HYPOCHROMIC MICROCYTE

18
Q

ABNORMAL PRODUCTION OF MEGAKARYOCYTE

A

DYSMEGAKARYPOIESIS

19
Q

SHEDS OF TO BECOME PLT

A

MEGAKARYOCYTE

20
Q

2 TYPES OF MDS

A

PRIMARY MDS
THERAPY RELATED MDS

21
Q

PRIMARY MDS

A
  1. ENVIRONMENTAL EXPOSURE
  2. MUTATION CAUSED BY CHEMICAL, RADIATION , VIRAL INFECTION OR SMOKING
  3. GENETIC INHERITANCE OF HEMATOLOGIC DISORDER
22
Q

CLASSIFICATION OF MDS RELIES ON MORPHOLOGY

23
Q

FAB CLASSIFICATION

A

RELIES ON MORPHOLOGY
DOES NOT ADDRESS THERAPY RELATED OR HEREDITARY FORMS
DOES NOT CONSIDER CHILDHOOD MDS

24
Q

WHO CLASSIFICATION

A

RETAINS FAB FEATURES
RECOGNIZE MOLECULAR, CYTOGENETIC AND IMMUNOLOGIC CHARACTERISTIC
REMOVE CATEGORIES OF CMML AND RAEB-T

25
3 TYPES REFRACTORY CYTOPENIA WITH UNILINEAGE DYSPLSIA
1. REFRACTORY ANEMIA 2. REFRACTORY NEUTROPENIA 3. REFRACTORY THROMBOCYTOPENIA
26
RCUD PROGNOSIS PROGRESSION
5 YEARS PROGNOSIS 6 % PROGRESSION
27
MDS-RS-SLD PROGNOSIS PROGRESSION
5 YEARS 2 %
28
MDS-RS-MLD PROGNOSIS PROGRESSION
33 MONTHS 11 %
29
MDS EB2 PROGNOSIS PROGRESSION
<2 YEARS 33 %
30
MDS EB1 PROGNOSIS PROGRESSION
< 2 YEARS 25 %
31
MDS ASSOCIATED WITH DEL (5Q)
9 MONTHS RARE OR NO
32
GENE THAT CONTRIBUTE TO THE SEVERITY OF MDS-RS-SLD
SF3B1
33
HOW MANY % ARE THERE IN CASES OF RARS?
80 %
34
+ AUER RODS
MDS EB2
35
WHAT CHROMOSOME IS MISSING IN MDS ASSOCIATED W ISOLATED DEL 5Q
CHROMOSOME 5
36
OCCURS MOST ON OLDER WOMEN
MDS ASSOCIATED WITH ASSOCIATED WITH DEL 5Q
37
LACKS SPECIFIC NECESSARY CLASSIFICATIONS
MYELODYSPLASTIC SYNDROME
38
KNOWN A DENOVO MDS
CHILDHOOD MDS
39
RAEBIT
REFRACTORY ANEMIA WITH EXCESS BLAST IN TRANSFORMATION
40
PERIPHERAL BLOOD PERCENTAGE IN FAB CASSIFICATION
5 %
41
BM PERCENTAGE IN FAB CASSIFICATION
20-30 %
42
AUER ROD +
FAB CLASSIFICATION