QUANTI (ANACHEM) Flashcards
May be defined as the application of the procedures of Quantitative Analytical Chemistry.
QUANTITATIVE PHARMACEUTICAL CHEMISTRY
To the analysis and determination of the PURITY AND QUALITY OF DRUGS AND CHEMICALS used in pharmacy, official in USP/NF.
QPC
To the ANALYSIS OF MEDICINAL AGENTS AND THEIR METABOLITES found in biological system.
QPC
the DETERMINATION OF THE VOLUME of a solution of known concentration required to react with a given amount of the substance to be analyzed.
VOLUMETRIC ANALYSIS
chromatographic, spectrophotometric, electrometric, thermal conductrimetric, refractrometric, polarimetric, etc.
INSTRUMENTAL TECHNIQUES APPLIED IN QPC
Is achieved NOT BY HASTE, BUT BY PLANNING THE WORK so that two or more operations
may be carried out at one time.
ECONOMY OF TIME
The reagents used in quantitative analysis must be
PURE
Refers to the NUMERICAL DIFFERENCE between a MEASURED value and the TRUE value.
ERRORS
Of any quantity is really something never know.
TRUE VALUE
Also known as RANDOM ERROR
INDETERMINATE ERRORS
Cause: Inability of the eye to detect slight changes in a readout device.
INDETERMINATE ERRORS
Also known as SYSTEMATIC ERROR.
DETERMINATE ERRORS
Caused by faulty procedure
ERROR OF METHOD
Due to poor construction or calibration
APPARATUS ERROR
Are made of high-grade porcelain
CAN WITHSTAND HIGH TEMPERATURES
Use in the ignition of most drugs and precipitates
CRUCIBLE
in evaporation, The dish should be covered by an
INVERTED FUNNEL or WATCH GLASS
Means that two consecutive weighings do not differs by more than 0.5mg/g of
substances taken for the determination, the second weighing following an additional hour of drying.
DRIED TO CONSTANT WEIGHT
An object is said to be CONSTANT WEIGHT when two consecutive weighing after
heating and cooling do not differ by
MORE THAN 0.2 mg
A GLASS VESSEL rendered AIRTIGHT by means of ground contact surfaces, used to
MAINTAIN A DRY ATMOSPHERE for object that might be affected by moisture or carbon
dioxide.
DESICCATOR
The desiccator is divided into two (2) compartments separated by a
PERFORATED PORCELAIN PLATE
maintains a constant weight on the beam at all times, and the object is weighed by displacing its equivalent weight from the beam.
ANALYTICAL BALANCE
Is the act of adding and measuring the volume of titrant used in the assay by
means of a buret
TITRATION
Is the theoretical point at which equivalent amount of each (analyte and titrant)
have reacted.
STOICHIOMETRIC POINT / EQUIVALENCE POINT
Is a concentration expression and is defined as the number of equivalents of solute per liter (equiv/liter) or milliequivalents per milliliter (meq/mL) of solution.
NORMALITY
Is an expression of the concentration of a solution in terms of MOLES PER LITER or the
number of moles per liter of solution.
MOLARITY
Is determination of the concentration (Normality, Molarity) of a solution.
STANDARDIZATION
May be accomplished by the USE OF ANOTHER STANDARD SOLUTION of known
concentration (Normality or Molarity).
SECONDARY STANDARD
Is defined as the weight of a substance chemically equivalent to 1mL of a standard
solution.
TITER
Graduated glass tubes of uniform bore throughout the whole length, used in the
measurement of variable quantities of liquids.
BURETTE
Should be graduated to deliver at standard temperature the volume indicated.
PIPETTE
a type of pipette that is usually used
MEASURING PIPETTE
Are used to prepare a standard solution.
VOLUMETRIC FLASK
Are complex organic compounds used to:
1. Determine the end points in neutralization process,
2. Determine hydrogen-ion concentrations [H+], or
3. Indicate that a desired change in pH has been affected.
INDICATORS
Attributes the color of indicators to certain groupings of the elements of a compound, and the change in color to a CHANGE IN MOLECULAR STRUCTURE .
ORGANIC THEORY
indicators used When a STRONG ACID (sample) is titrated with a STRONG ALKALI (titrant) or vice versa
methyl orange
methyl red
phenolphthalein
indicators used When a WEAK ACID (sample) is titrated with STRONG ALKALI (titrant)
phenolphthalein
indicators used When a WEAK ALKALI (sample) is titrated with a STRONG ACID (titrant)
methyl res
indicators used When a WEAK ALKALI (sample) is titrated with a STRONG ACID (titrant)
methyl red
A ________ should never be titrated with a ________
WEAK ALKALI, WEAK ACID