EXTRACTIVE AND CRUDE FIBER CONTENT Flashcards
Is the WITHDRAWAL OF DESIRED CONSTITUENTS from crude drugs through the use of selected solvents in which the desired constituents are soluble.
EXTRACTIVE
Are VEGETABLE OR ANIMAL DRUGS that have undergone no other processes than collection, cleaning and drying.
CRUDE DRUGS
used in the manufacture of some pharmaceutical preparations
Semi-liquids or liquids of syrupy consistency
used in pill, ointment and suppositories
Plastic masses known as pilular or solid extracts
PLASTIC MASSES are known as
PILULAR / SOLID EXTRACTS
suited for incorporation into a POWDERED FORMULATION as in capsules, powders or tablets
Dry powders or Powdered extracts
A process in which the comminuted drugs is permitted to SOAK IN THE MENSTRUUM until the cellular structures is softened and penetrated by the menstruum and the soluble constituents are dissolved.
MACERATION
Is a process in which comminuted drug is extracted of its soluble constituents of the SLOW PASSAGE of a suitable solvent through a column of the drug. The drug is packed in extraction apparatus – the percolator with the extractive collected called the percolate.
PERCOLATION
This is a form of maceration in which GENTLE HEAT is used during the process.
DIGESTION
are prepared by MACERATING THE DRUGS for a SHORT PERIOD OF TIME with either cold or boiling water
FRESH INFUSION
an infusion is made with ½ - 1 oz dried herb to 2 pints of water, BREWED FOR SEVERAL HOURS OR OVERNIGHT
HERBAL INFUSION
This once popular process extracts water soluble and heat stable constituents from crude drugs by BOILING in water for 15 minutes, COOLING, STRAINING, and PASSING sufficient cold water through the drug to produce the required volume
DECOCTION
are found to be MOST EFFECTIVE and have MINIMAL SIDE EFFECTS.
DECOCTIONS
It is prepared from fresh herbs and is CONSUMED IMMEDIATELY after preparation and therefore there is no risk of adulteration, getting stale or degradation and untoward reaction.
DECOCTION
max ng timbol
25g
ADVANTAGES:
- w/o filtration
- can become the solvent after extraction
DISADVANTAGES:
- use small amount of sample
- expensive apparatus
CONTINUOUS DISTILLATION / SOXHLET EXTRACTION
ADVANTAGES:
- big amount of sample
- cheaper apparatus
DISADVANTAGES:
- w/ filtration
REFLUX DISTILLATION
solven is also known as
menstruum
solvent:
mabilis mag evaporate (maceration)
ETHER
a good solvent for RESINOUS matter & ALKALOIDS
ALCOHOL
Is the residue, consisting chiefly of CELLULOSE, that REMAINS UNDISSOLVED after successive treatment with boiling acids and alkali.
CRUDE FIBER
The method of analysis of fatty substances, waxes, resin, etc., usually consist of the determination of a NUMBER OF PHYSICAL & CHEMICAL PROPERTIES or values known as _______
CONSTANT
Acid Value also known as
ACID NUMBER
ACIDITY INDEX
defined as the number of milligrams of KOH necessary to neutralize the FREE ACIDS in 1 g of oil, fat, wax, resin, balsam, and similar substances.
ACID VALUE / ACID NUMBER / ACIDITY INDEX
Saponification Value or Saponification Number is also known as
KOETTSDORFER NUMBER
defined as the number of milligrams of KOH required to NEUTRALIZE THE FREE ACIDS & SAPONIFY THE ESTERS contained in 1 g of fat, fatty or volatile oil, wax, resin, balsam, and similar substances.
SAPONIFICATION VALUE
Is defined as the number of milligrams of KOH required to SAPONIFY THE ESTERS in 1 g of a fatty or volatile oil, fats, wax, balsam, resin.
ESTER VALUE / ESTER NUMBER
may also be calculated in the same manner as the Saponification value
ESTER NUMBER
defined as the substances PRESENT IN OILS & FATS that are NOT SAPONIFIED by alkali hydroxides but are soluble in ordinary fat solvents
UNSAPONIFIABLE MATTER
When oil and fats are saponified, there remains a small amount of residue that may consist of _____ in VEGETABLE oils and ______ in ANIMALS
PHYTOSTEROL - plants
CHOLESTEROL - animals
Is the number of grams of IODINE absorbed under specified conditions by 100 g of oil, fat, wax, or other substances.
IODINE VALUE / IODINE NUMBER
This value is a quantitative measure of the PROPORTION OF UNSATURATED FATTY ACIDS PRESENT, both free and uncombined as esters, that have the property of absorbing iodine
IODINE VALUE / IODINE NUMBER
fats that has 2-3 double bonds
POLYUNSATURATED
fats with single bonds
SATURATED
fats with one double bond
MONOUNSATURATED
have a VERY HIGH IODINE NUMBER, above 120, since they contain a large proportion of unsaturated fatty acids.
DRYING OIL
DRYING OIL IODINE NUMBER
ABOVE 120
have relatively LOW iodine number below 100.
NON-DRYING OIL
NON-DRYING OIL IODINE NUMBER
BELOW 100
have INTERMEDIATE iodine values, that is between 100 and 120
SEMI-DRYING OIL
SEMI-DRYING OIL IODINE NUMBER
BETWEEN 100 & 120
METHODS OF IODINE VALUE DETERMINATION THAT ARE NOT USED ANYMORE
Hübl
Hanus
Wijs
method of iodine value determination that is FIRST to be disregarded bcs una nawala sa market
HUBL
the number of milligrams of Potassium hydroxide equivalent to the hydroxyl content of 1 gram o the substance
HYDROXYL VALUE
This constant gives an indication of the IDENTITY & PURITY OF FATTY SUBSTANCES possessing alcoholic hydroxyl groups.
HYDROXYL VALUE
Is the number of milligrams of Potassium hydroxide required to NEUTRALIZE THE ACETIC ACID obtained by the saponification of 1 gram of acetylated fatty acids.
ACETYL VALUE OF FATTY ACIDS
Certain fatty oils particularly those of ANIMAL ORIGIN which are NOT HIGHLY REFINED, frequently contain some moisture and non-fatty tissue residues.
WATER & SEDIMENTS IN FATTY OILS
Also known as ETHEREAL oils or ESSENTIAL oils
VOLATILE OILS
Are generally complex products composed of MIXTURE OF COMPOUNDS of widely variant chemical characteristics
VOLATILE OILS
Orange, Caraway, Corriander, Lemon, Turpentine, Rosemary
OIL LIGHTER THAN WATER
Anise, Cinnamon, Clove, Sasafras
OIL HEAVIER THAN WATER
Hydrocarbons
Alcohols
Esters
Ketones
LIGHTER THAN WATER
Aldehydes
Phenols
Phenolic derivatives
Esters
HEAVIER THAN WATER
Specific gravity of official volatile oil range between
0.84 & 1.2
determine optically active substances
ROTARY POWER
The ________ the congealing point of the oil the MORE they are valued
HIGHER
ASSAY FOR ALCOHOL CONTENT
* APPARATUS:
Acetylization Flask
ASSAY FOR PHENOL CONTENT
* APPARATUS:
CASIA FLASK
ASSAY FOR VOLATILE OIL IN SPIRITS
* APPARATUS:
BABCOCK BOTTLE
MAY BE DEFINED AS CHEMICAL SUBSTANCES
1. Which are obtained from plant, animal or synthetic sources
2. Contain organic nitrogen(s) within their chemical structure
3. Possess physiological activity
ALKALOIDS
Alkaloids (R3N) arealso called
FREE ALKALOIDS
are SPARINGLY SOLUBLE in water but readily soluble in most organic solvent.
ALKALOIDS
are READILY SOLUBLE in water and sparingly soluble in organic solvents
ALKALOIDAL SALTS
Alkaloids combine directly with _______ to form salts that are usually soluble in water but insoluble in certain organic solvents
ACIDS
Alkaloids combine directly with acids to form _____ that are usually soluble in water but insoluble in certain organic solvents
SALTS
Alkaloids combine directly with acids to form salts that are usually __________ but insoluble in certain organic solvents
SOLUBLE IN WATER
Alkaloids are liberated from ___________ of their salts by alkalines
AQ. SOLUTIONS
Alkaloids are liberated from aqueous solutions of their salts by ________
ALKALINES
Alkaloids form _____________ with a considerable number of reagents, especially with the salts of some HEAVY METALS, such as mercury, gold, and platinum.
HIGHLY INSOLUBLE PRECIPITATES
Is prepared by slowly adding a 10% solution of Potassium iodide to RED MERCURIC IODIDE until all is dissolved.
VALSER’S
VALSER’S REAGENT POSITIVE RESULT
WHITE PPT
Is a solution containing 1.275 g of iodine and 3.6 g Potassium iodide dissolved in sufficient distilled water to make 100 mL
WAGNER’S
WAGNER’S POSITIVE RESULT
REDDISH BROWN PPT
s a solution of 1.3558 g of MERCURIC CHLORIDE in 60 mL of water and mixed with 5 g of Potassium Iodide in 10 mL of water and the mixture diluted to 100 mL with water.
MAYER’S
MAYER’S POSITIVE RESULT
YELLOW PPT
Solution of POTASSIUM BISMUTH IODIDE
DRAGGENDORFF’S
DRAGGENDORFF’S POSITIVE RESULT
ORANGE PPT
If the percent of extractive represents the TOTAL OF A CLASS of plant principles, such as; alkaloids, glycosides, etc.
PROXIMATE ASSAY
If the PERCENT EXTRACTIVE FROM A CRUDE DRUG represents a single chemical species, such as morphine
ULTIMATE ASSAY
CAFFEINATED COFFEE SPECS:
NLT 1%
NMT 2%
DECAF COFFEE SPECS
NMT 0.8%